Hereditary Risk Factors for Thyroid Cancer
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: •Referral to Genetic Counselor, if indicated.
- Who it may be relevant to
- Registry conditions: Thyroid Cancer. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Thyroid cancers can occur sporadically, but can also be found as tumors that cluster in families with other cancers or genetic syndromes. Researchers are studying thyroid cancer in children and families, with a particular interest in understanding genes and other factors that may put individuals at risk for developing thyroid cancer and thyroid nodules. * In this study, family and medical history information is collected alongside a blood or saliva sample for genetic studies. * Individuals with a past or present childhood thyroid cancer/nodule or a thyroid cancer suspected to be inherited in their family are invited to participate.
Detailed description
The purpose of this research study is to learn more about risk factors for inherited thyroid cancer.
The investigators would like to use the participant DNA to look for alterations in genes. The investigator will perform DNA sequencing and other genetic studies to identify errors in the genes that may contribute to the formation of thyroid nodules and cancer.
Interventions
- Genetic •Referral to Genetic Counselor, if indicated
Primary outcome measures
- Number of participants who have childhood or suspected familial thyroid nodules/cancer [Time frame: 2 years]
- Number of germline mutations identified associated with thyroid cancer predisposition [Time frame: 2 years]
- Prevalence of suspected familial thyroid cancer among those with childhood thyroid nodules/cancer [Time frame: 2 years]
Eligibility criteria
Inclusion criteria
- Individual pediatric patient with current or previous known or suspected thyroid cancer or nodule(s).
- Individual adult patient with current or previous known or suspected thyroid cancer or nodule(s) if they come from a family with a high suspicion of hereditary cancer (as below).
- Individuals from families with a high suspicion of hereditary thyroid cancer:
- Families with a current or previous diagnosis of a thyroid cancer/nodule occurring in childhood (<18 years old).
- Families with a high suspicion of hereditary thyroid cancer/nodules other than above to include:
- Families with thyroid cancer in multiple individuals
- Families with thyroid cancer and a known genetic syndrome
- Families with thyroid cancer and a suspected genetic syndrome (e.g. multiple childhood cancers in the family, multiple primary cancers, multiple endocrinopathies, etc.)
Exclusion criteria
- Individuals who are unable to give informed consent.
- Individuals who are unable to complete study materials.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Non-randomized
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Screening
Study locations
United States · 1 center
- Dana Farber Cancer Institute — Boston
Identifiers
NCT: NCT02747888 · 15-159