Quality of Pediatric Resuscitation in a Multicenter Collaborative
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Cardiac Arrest, Cardiopulmonary Arrest. Basic parameters: 0 years — 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States, Australia, Brazil, Canada, Colombia +10
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Quality of Pediatric Resuscitation in a Multicenter Collaborative: An Observational Study
Overview
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.
Detailed description
Cardiac arrests in children are a major public health problem. Thousands of children each year in the USA are treated with cardiopulmonary resuscitation (CPR) and managed after their cardiac arrest. Neurological outcomes following these in-hospital CPR events are often abnormal. As children with neurological deficits following CPR are a major burden for families and society, improving neurological outcomes through superior chest compression delivery during CPR and optimal care and management after cardiac arrest is an important clinical goal.
Therefore, the objective of this investigation is to obtain evidentiary support to associate the relationship of quantitative CPR quality data (depth, rate, chest compressions (CC) fraction, compression release) during CPR, post-cardiac arrest care (PCAC) and patient survival in those children who suffer an arrest within the study (RES-Q) Network.
Primary outcome measures
- Aggregate score composed of American Heart Association (AHA) recommended depth, rate, and chest compression fraction during CPR [Time frame: 10 Years]
Eligibility criteria
Inclusion criteria
- Patient received chest compressions for at least 1 minute
- Patient between gestational age ≥37 weeks and 18 years of age
Exclusion criteria
- Patient on veno-arterial extracorporeal membrane oxygenation (ECMO) therapy at beginning of CPR event
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
United States · 40 centers
- Kaiser Permanente — Los Angeles
- Cedars-Sinai Medical Center — Los Angeles
- Valley Children's Hospital — Madera
- Chldren's Hospital of Orange County — Orange
- Stanford University — Palo Alto
- Rady Children's Hospital — San Diego
- Children's Colorado — Aurora
- Nemours Children's Hospital — Wilmington
- … and 32 more centers
Australia · 3 centers
- The Children's Hospital at Westmead — Westmead
- Perth Children's Hospital — Nedlands
- Queensland Children's Hospital — South Brisbane
Canada · 3 centers
- Stollery Children's Hospital — Edmonton
- BC Children's — Vancouver
- Alberta Children's — Calgary
Japan · 3 centers
- Aichi Children's Health and Medical Center — Aichi
- Kobe Children's Hospital (Hyogo Prefectural) — Kobe
- Tokyo Metropolitan Children's Medical Center — Tokyo
Singapore · 2 centers
- National University Hospital — Singapore
- KK Women's & Children's Hospital — Singapore
Brazil · 1 center
- Sabara Hospital Infantil — São Paulo
Colombia · 1 center
- Instituto Roosevelt — Bogotá
Italy · 1 center
- IRCCS Ospedale Pediatrico Bambino Gesù — Roma
Netherlands · 1 center
- Erasmus MC - Sophia Children's — Rotterdam
New Zealand · 1 center
- Starship Children's Hospital — Auckland
South Korea · 1 center
- Seoul National University Bundang Hospital — Seongnam
Spain · 1 center
- Gregorio Marañón General University Hospital — Madrid
Taiwan · 1 center
- National Taiwan University Hospital — Taipei
Thailand · 1 center
- King Chulalongkorn University — Bangkok
United Kingdom · 1 center
- Great Ormond Street Hospital — London
Publications
- Niles DE, Duval-Arnould J, Skellett S, Knight L, Su F, Raymond TT, Sweberg T, Sen AI, Atkins DL, Friess SH, de Caen AR, Kurosawa H, Sutton RM, Wolfe H, Berg RA, Silver A, Hunt EA, Nadkarni VM; pediatric Resuscitation Quality (pediRES-Q) Collaborative Investigators. Characterization of Pediatric In-Hospital Cardiopulmonary Resuscitation Quality Metrics Across an International Resuscitation Collabor PMID 29533355
- Sweberg T, Sen AI, Mullan PC, Cheng A, Knight L, Del Castillo J, Ikeyama T, Seshadri R, Hazinski MF, Raymond T, Niles DE, Nadkarni V, Wolfe H; pediatric resuscitation quality (pediRES-Q) collaborative investigators. Description of hot debriefings after in-hospital cardiac arrests in an international pediatric quality improvement collaborative. Resuscitation. 2018 Jul;128:181-187. doi: 10.1016/j.re PMID 29768181
- Pfeiffer S, Lauridsen KG, Wenger J, Hunt EA, Haskell S, Atkins DL, Duval-Arnould JM, Knight LJ, Cheng A, Gilfoyle E, Su F, Balikai S, Skellett S, Hui MY, Niles DE, Roberts JS, Nadkarni VM, Tegtmeyer K, Dewan M; Pediatric Resuscitation Quality Collaborative Investigators. Code Team Structure and Training in the Pediatric Resuscitation Quality International Collaborative. Pediatr Emerg Care. 2021 Au PMID 31045955
- Esangbedo I, Yu P, Raymond T, Niles DE, Hanna R, Zhang X, Wolfe H, Griffis H, Nadkarni V; Pediatric Resuscitation Quality (pediRES-Q) Collaborative Investigators. Pediatric in-hospital CPR quality at night and on weekends. Resuscitation. 2020 Jan 1;146:56-63. doi: 10.1016/j.resuscitation.2019.10.039. Epub 2019 Nov 14. PMID 31734222
- Wolfe HA, Wenger J, Sutton R, Seshadri R, Niles DE, Nadkarni V, Duval-Arnould J, Sen AI, Cheng A. Cold Debriefings after In-hospital Cardiac Arrest in an International Pediatric Resuscitation Quality Improvement Collaborative. Pediatr Qual Saf. 2020 Jul 8;5(4):e319. doi: 10.1097/pq9.0000000000000319. eCollection 2020 Jul-Aug. PMID 32766493
- Stromberg D, Raymond TT, Centers G, Vaez Z, Je S, Thomas A, Nadkarni V, Howsmon DP; PediRes-Q Investigators. Interposed abdominal compression CPR in pediatric cardiac arrest: early results from a multicenter comparison to standard CPR. Resuscitation. 2025 Oct;215:110676. doi: 10.1016/j.resuscitation.2025.110676. Epub 2025 Jun 16. PMID 40516688
- Jensen S, Loeb D, Zackoff M, Lautz AJ, Zhang B, Gray J, Tegtmeyer K, Dewan M. CPR coach presence is associated with increased cardiopulmonary resuscitation guideline adherence in pediatric in-hospital cardiac arrest: a retrospective cohort study. Resuscitation. 2025 Oct;215:110664. doi: 10.1016/j.resuscitation.2025.110664. Epub 2025 Jun 4. PMID 40480368
- Raymond TT, Yu P, Esangbedo I, Sweberg T, Lasa JJ, Zhang X, Griffis H, Nadkarni V; pediRES-Q investigators. Outcomes after extracorporeal cardiopulmonary resuscitation in pediatric in-hospital cardiac arrest: does quality of CPR matter? Resuscitation. 2025 Jun;211:110599. doi: 10.1016/j.resuscitation.2025.110599. Epub 2025 Apr 7. PMID 40204231
Identifiers
NCT: NCT02708134 · 15-012099