Menu
Recruiting NCT02362685

Metabolic Exercise Testing

— Observational Metabolic Myopathies Exercise Test Myalgia

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: functional test, matching genotype with phenotype.
Who it may be relevant to
Registry conditions: Metabolic Myopathies, Exercise Test, Myalgia. Basic parameters: from 5 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
France
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Exercise Testing in Metabolic Myopathies

Overview

Exertional symptoms are the hallmarks of metabolic myopathies, supporting the concept of using functional tests when this diagnosis is suspected. Exercise increases the concentration of muscle metabolites in the venous blood supply (e.g. lactate, pyruvate, and ammonia) especially during recovery. The purpose of this study is to compare the results of exercise testing with to the data from muscle biopsy or genetic analysis.

Interventions

  • Device functional test
    subjects perform a metabolic exercise testing
  • Genetic matching genotype with phenotype

Primary outcome measures

  • Whole-body dynamic exercise [Time frame: Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed]
  • Grip-test [Time frame: Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed]
  • Blood tests [Time frame: Participants will be followed for an expected average of 1 year to determine whether a muscle biopsy is performed]

Eligibility criteria

Inclusion criteria

  • Referred to the Physiology Department of Brest Hospital for a metabolic exercise test
  • Ability to provide informed consent

Exclusion criteria

  • Contraindication(s) to perform cardiopulmonary exercise testing (ATS/ACCP statement on cardiopulmonary exercise testing, Am J respi Care Med 167: 211-77, 2003)
  • Pregnancy or unknown pregnancy status.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Cohort

Study locations

France · 1 center
  • Centre Hospitalier Régional Universitaire — Brest

Identifiers

NCT: NCT02362685 · RANNOU

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗