Validation of Drug Assays in Various Biological Matrices
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: antivirals, antimicrobials, oral contraceptive, erectile dysfunction agents.
- Who it may be relevant to
- Registry conditions: Infection. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United Kingdom
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This study aims to ensure that assays that measure drug concentrations are accurate and precise in different matrices when quantified using high performance liquid chromatography -tandem mass spectrometry (HPLC-MS/MS). The study involves collecting samples of various bodily fluids to quantify antimicrobials, antivirals, oral contraceptives and erectile dysfunction agents. Samples will also be obtained from individuals not receiving these medications for quality control purposes.
Interventions
- Other antivirals, antimicrobials, oral contraceptive, erectile dysfunction agents
Primary outcome measures
- To measure drug concentrations using high performance liquid chromatography -tandem mass spectrometry (HPLC-MS/MS) (accuracy and precision of assays that measure drug concentrations) [Time frame: Follow up up to 5 years]
Eligibility criteria
Inclusion criteria
- > 18 years of age
Exclusion criteria
- Unable to give informed consent
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-only
Study locations
United Kingdom · 1 center
- Royal Liverpool University Hospital — Liverpool
Identifiers
NCT: NCT02283112 · RLUH 4520