OCT Angiography in Wet AMD
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Optical Coherence Tomography.
- Who it may be relevant to
- Registry conditions: Neovascular (Wet) Age-related Macular Degeneration (AMD). Basic parameters: 50 years — 100 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Optical Coherence Tomography Angiography in Neovascular Age-related Macular Degeneration
Overview
The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: 1. diagnose the presence of new blood vessels in wet age-related macular degeneration (AMD) 2. evaluate patients undergoing treatment for wet AMD 3. determine if reduced flow to the choroid is a risk factor for developing wet AMD.
Interventions
- Device Optical Coherence Tomography
Primary outcome measures
- Measure of choroidal neovascular (CNV) vessel area in mm2 [Time frame: 1 year]
- Measure of CNV membrane area in mm2 [Time frame: 1 year]
- Measure of CNV length density in mm [Time frame: 1 year]
- Measure of retinal fluid volume in mm3 [Time frame: 1 year]
- Measure of drusen area in mm2 [Time frame: 3 years]
Eligibility criteria
Inclusion Criteria (Groups with wet AMD):
- Adults aged 50 and older with clinical findings of treatment-naïve (never treated) neovascular AMD with active new blood vessel growth confirmed by clinical testing will be considered
Inclusion Criteria (Group with healthy eyes)
- No evidence of retinal disease
- Refractive error greater than +3.00 diopters or -7.00 diopters (glasses Rx)
- No recent eye surgery in the last 4 months
- No significant cataract to interfere with the quality of the imaging
Exclusion Criteria (All Groups):
- Inability to give informed consent
- Significant kidney disease
- Blood pressure greater than 180/110
- Previous macular laser treatment
- Inability to maintain stable fixation during OCT imaging
- Visual acuity worse than 20/200
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
United States · 1 center
- Casey Eye Institute, Oregon Health & Science University — Portland
Identifiers
NCT: NCT02253030 · IRB#000010535