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Enrolling by invitation NCT01517425

Evaluating Cardiovascular Phenotypes Using Induced Pluripotent Stem Cells

— Observational Coronary Artery Disease

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Coronary Artery Disease. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

This research is being done to understand how changes in DNA may put people at risk for developing coronary artery disease. Stem cells will be made using cells from blood and/or skin biopsy samples. We are trying to understand which specific changes in DNA negatively impact a person's health.

Primary outcome measures

  • iPSC development [Time frame: five years]

Eligibility criteria

Inclusion criteria

Cases:

  • Previously enrolled in the CAD module of the Genebank at Scripps Clinic Registry
  • Eligible to have their blood drawn
  • Be reliable, cooperative and willing to comply with all protocol-specified procedures
  • Able to understand and grant informed consent

Controls:

  • Previously enrolled in the Healthy Elderly Active Longevity (HEAL) Cohort
  • Eligible to have their blood drawn
  • Be reliable, cooperative and willing to comply with all protocol-specified procedures
  • Able to understand and grant informed consent

Exclusion criteria

  • Unwilling or unable to grant informed consent.
  • Have a significant medical condition that in the Investigator's opinion may interfere with subject's study participation.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Case-control

Study locations

United States · 1 center
  • Scripps Translational Science Institute — La Jolla

Identifiers

NCT: NCT01517425 · 11-5676

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗