Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Sepsis, Severe Sepsis, Septic Shock, Multi-organ Failure. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Alveolar Dead Space as Predictor of Multi-organ Failure and Mortality in Medical Intensive Care Patients With Sepsis Requiring Mechanical Ventilation
Overview
This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure. The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.
Detailed description
The patient will be followed during their ICU stay up to two weeks while on mechanical ventilation.
Patient will be followed daily for the initial 48 hours and then once per week for 2 weeks while mechanically ventilated.
Primary outcome measures
- Multi-organ failure [Time frame: daily for 48 hours then weekly for 2 weeks.]
Secondary outcome measures (1)
- Mortality [Time frame: ICU mortality]
Eligibility criteria
Inclusion criteria
- Adults with severe sepsis or septic shock on mechanical ventilation
- Enrolled in the initial six hours of ICU admission
Exclusion criteria
- Patients with withdrawal or hospice order.
- Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission.
- Patients with COPD.
- Patients transferred from outside ICU with ongoing sepsis management for more than six hours.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
United States · 1 center
- Memorial Hermann Hospital — Houston
Identifiers
NCT: NCT01315782 · HSC-MS-10-0555