Language in Primary Progressive Aphasia
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Primary Progressive Aphasia. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Asymmetric Neurodegeneration and Language in Primary Progressive Aphasia
Overview
The purpose of this study is to further define the neurological and linguistic deterioration in primary progressive aphasia.
Detailed description
The Language in Primary Progressive Aphasia (PPA) aims to understand the behavioral, anatomical and physiological changes in people with PPA throughout the course of the illness. The researchers in this study want to increase awareness of PPA, educate others about this unique disorder, and to encourage more research to eventually develop therapies.
During the three-day research program, participants will be asked to undergo neuropsychological testing (paper and pencil tests that evaluate cognition), advanced imaging (MRI and PET), cognitive experiments, and other computer and language testing batteries. Participants may be asked to return every two years to complete the same measures.
For participants not living near Chicago, IL, flights and accommodations (for both the person with PPA and their companion) will be covered by the study.
Primary outcome measures
- Neuropsychological variables [Time frame: Immediately after testing and at two years post-testing]
Eligibility criteria
Inclusion criteria
- Diagnosis of primary progressive aphasia
- Right-handed
- Native English speaker
- Visual acuity of 20/30 corrected
- Adequate hearing to follow conversation
- Safe for an MRI scan
Exclusion criteria
- Left-handedness
- Claustrophobia
- Presence of significant medical illness that initially or in the future could interfere with continued participation in the study
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
United States · 1 center
- Northwestern University — Chicago
Publications
- Mesulam MM. Slowly progressive aphasia without generalized dementia. Ann Neurol. 1982 Jun;11(6):592-8. doi: 10.1002/ana.410110607. PMID 7114808
- Weintraub S, Rubin NP, Mesulam MM. Primary progressive aphasia. Longitudinal course, neuropsychological profile, and language features. Arch Neurol. 1990 Dec;47(12):1329-35. doi: 10.1001/archneur.1990.00530120075013. PMID 2252450
- Mesulam MM, Coventry C, Kuang A, Bigio EH, Mao Q, Flanagan ME, Gefen T, Sridhar J, Geula C, Zhang H, Weintraub S, Rogalski EJ. Memory Resilience in Alzheimer Disease With Primary Progressive Aphasia. Neurology. 2021 Feb 9;96(6):e916-e925. doi: 10.1212/WNL.0000000000011397. Epub 2021 Jan 13. PMID 33441454
Identifiers
NCT: NCT00537004 · IA0125 · R01AG077444