Studies of Blood Flow to the Brain During Thought

Official title

Regional Cerebral Blood Flow Studies of Object Perception, Identification, Localization, and Memory

Overview

The purpose of this study is to use brain imaging technology to measure changes in blood flow to areas in the brain as individuals perform intellectual tasks. This study will use functional magnetic resonance imaging (fMRI) to examine blood flow to areas of the brain as participants engage in tasks associated with visual perception, visual recognition, and memory.

Detailed description

Objective:

Our goal is to study the functional organization of the intact human brain by combining cognitive tasks and neuroimaging. Functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG) and electroencephalography (EEG) will be used to measure brain activity in healthy human subjects engaged in performing cognitive tasks. These tasks will address specific questions concerning the neural systems that mediate perception, attention, memory, decision-making, emotion, plasticity and social interactions. fMRI and MEG, respectively, will be employed to investigate the spatial and temporal aspects of these neural systems.

Study Population:

Normal volunteer participants aged 18-65, who are in good general health will be recruited from the local community and studied under this minimal risk protocol.

Design:

Subjects will perform cognitive tasks in behavioral and/or neuroimaging sessions (fMRI or MEG).

Outcome Measures:

Behavior as performance on cognitive tasks, and brain activity (fMRI and MEG) will be combined to yield information about the neural correlates and processes underlying different aspects of human cognition including visual perception, memory, learning, emotion, social cognition, decision-making and attention.

Primary outcome measures

• Cognitive tasks and neuroimaging. [Time frame: ongoing]

Eligibility criteria

• INCLUSION CRITERIA:
• Healthy adults, with at least a high school education, aged 18 to 65 years, will be recruited to participate in the study.
• Able to read and write in English to guarantee understanding of all written and spoken instructions, which are in English.

Exclusion criteria

Subjects will be excluded if they:

• have evidence of, or a history of:
• major medical, neurological or psychiatric illness
• serious head injury
• learning disability-drug or alcohol abuse or dependence in the past 3 months, except nicotine

-are taking prescription drugs or supplements that may affect brain function-

-have serious vision or hearing problems

In addition to the above, additional exclusion criteria apply for all MRI studies:

• Female subjects who are pregnant or have a positive pregnancy test 24 hours prior to an experiment will be excluded from neuroimaging studies.
• All subjects will be questioned prior to MRI scanning for possible occupational exposure to metal slivers or shavings, which may have become accidentally lodged in the tissues of the head or neck. Subjects with surgical clips or shrapnel in or near the brain or blood vessels, subjects with cochlear implants, subjects with any metallic body in the eye or CNS, and subjects with any form of implant wire or metal device which may concentrate radiofrequency fields will be excluded from MRI scanning experiments because of possible risks during MRI scanning. Those whose history is suggestive of such a problem will also be excluded from the MRI portion of the experiments. They may still participate in the behavioral and MEG experiments.
• Subjects unable to lie flat on their back for up to 3 hours may not be eligible to participate in MRI scans.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model

Cohort

Study locations

United States · 1 center

• National Institutes of Health Clinical Center — Bethesda

Publications

• Andersen RA, Asanuma C, Essick G, Siegel RM. Corticocortical connections of anatomically and physiologically defined subdivisions within the inferior parietal lobule. J Comp Neurol. 1990 Jun 1;296(1):65-113. doi: 10.1002/cne.902960106. PMID 2358530
• Baizer JS, Ungerleider LG, Desimone R. Organization of visual inputs to the inferior temporal and posterior parietal cortex in macaques. J Neurosci. 1991 Jan;11(1):168-90. doi: 10.1523/JNEUROSCI.11-01-00168.1991. PMID 1702462
• Barbas H, Mesulam MM. Organization of afferent input to subdivisions of area 8 in the rhesus monkey. J Comp Neurol. 1981 Aug 10;200(3):407-31. doi: 10.1002/cne.902000309. PMID 7276245
• Teichmann L, Hebart MN, Baker CI. Dynamic Representation of Multidimensional Object Properties in the Human Brain. J Neurosci. 2026 Mar 4;46(9):e1057252026. doi: 10.1523/JNEUROSCI.1057-25.2026. PMID 41629159
• Wardle SG, Rispoli B, Roopchansingh V, Baker CI. Brief Encounters with Real Objects Modulate the Medial Parietal But Not Occipitotemporal Cortex. J Neurosci. 2025 Dec 10;45(50):e0834252025. doi: 10.1523/JNEUROSCI.0834-25.2025. PMID 41193255
• Kan C, Stirnberg R, Montequin M, Gulban OF, Morgan AT, Bandettini PA, Huber L. T1234: A distortion-matched structural scan solution to misregistration of high resolution fMRI data. Magn Reson Med. 2025 Aug;94(2):713-723. doi: 10.1002/mrm.30480. Epub 2025 Mar 13. PMID 40079433
• Japee S, Jordan J, Licht J, Lokey S; Moebius Syndrome Research Consortium; Chen G, Snow J, Jabs EW, Webb BD, Engle EC, Manoli I, Baker C, Ungerleider LG. Inability to move one's face dampens facial expression perception. Cortex. 2023 Dec;169:35-49. doi: 10.1016/j.cortex.2023.08.014. Epub 2023 Sep 30. PMID 37852041
• Avery JA, Carrington M, Martin A. A common neural code for representing imagined and inferred tastes. Prog Neurobiol. 2023 Apr;223:102423. doi: 10.1016/j.pneurobio.2023.102423. Epub 2023 Feb 17. PMID 36805499

Identifiers

NCT: NCT00001360 · 930170 · 93-M-0170

Primary sources (government registries)

• ClinicalTrials.gov (US NIH)

View this study on ClinicalTrials.gov ↗