Urology

2,917 trials in this section

Recruiting NCT05327686

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

Phase II Interventional United States, Australia +2

Metastatic Renal Cell Carcinoma · Stage III Renal Cell Cancer AJCC v8 · Stage IV Renal Cell Cancer AJCC v8

Not yet recruiting NCT07658118

Safety and Preliminary Efficacy of Endoscopic Submucosal Injection of Hyaluronic Acid Into the Bladder Wall in Patients With Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)

Phase I Interventional —

Cystitis, Interstitial · Chronic Pain

Recruiting NCT06285292

Prospective and Comparative Evaluation of a Medical Device Composed of a Perineal Probe Connected to a Mobile Application in the Management of Stress Urinary Incontinence.

No phase Interventional France

Urinary Incontinence

Recruiting NCT07231627

AI Algorithm-Informed Biopsy for Prostate Cancer Detection With Indeterminate and Low-Risk Prostate MRI Lesions

No phase Interventional United States

Prostate Cancer

Recruiting NCT07669974

Comparing Two Training Methods for Learning Robot-Assisted Radical Prostatectomy

No phase Interventional Belgium

Robot-Assisted Radical Prostatectomy Training · Prostatectomy

Recruiting NCT06457919

A Study of Tinengotinib (TT-00420) in Combination With Standard Treatments in People With Prostate Cancer

Phase I / Phase II Interventional United States

Prostate Cancer

Recruiting NCT06041503

Enfortumab Vedotin With or Without Pembrolizumab in Rare Genitourinary Tumors (E-VIRTUE)

Phase II Interventional United States

Adenocarcinoma of the Bladder · Squamous Cell Carcinoma of the Bladder · Testicular Germ Cell Tumors

Recruiting NCT07321210

Radical Nephroureterectomy With vs Without Template Lymph Node Dissection in High-Risk Upper Tract Urothelial Carcinoma (T-LND UTUC)

No phase Interventional China

Upper Tract Urothelial Carcinoma · Lymph Node Dissection

Recruiting NCT05312671

Atezolizumab Plus Etoposide and Platinum in Small Cell Bladder Cancer

Phase II Interventional United States

Small Cell Neuroendocrine Carcinoma of Bladder · Bladder Cancer · Urothelial Carcinoma Bladder

Recruiting NCT03293563

UroCCR Database: French Research Network for Kidney Cancer -UroCCR

— Observational Belgium, France +2

Kidney Cancer

Recruiting NCT05558241

Micro-UltraSound In Cancer - Active Surveillance

No phase Interventional United States, Canada +2

Prostate Cancer

Recruiting NCT03354416

Profiling of Radiological Factors in Treatment and Outcomes in Prostate Cancer

— Observational United States

Prostatic Cancer · Prostatic Neoplams · Prostatic Hyperplasia

Not yet recruiting NCT07414992

A Study of Radiation Therapy and Cemiplimab With or Without Fianlimab In People With Bladder Cancer

Phase II Interventional United States

Bladder Urothelial Carcinoma

Recruiting NCT06835972

A Study of Abemaciclib and Cabozantinib in People With Clear Cell Renal Cell Carcinoma (ccRCC)

Phase I / Phase II Interventional United States

Metastatic Renal Cell Carcinoma · Translocation Renal Cell Carcinoma

Recruiting NCT06835725

Phase II Randomized Trial of 2 Versus 5 Fraction Prostate Stereotactic Ablative Radiotherapy for Intermediate Risk Prostate Cancer

Phase II Interventional Canada

Prostate CA

Not yet recruiting NCT07664397

Imaging Study of [89Zr]DFO-YS5 for Cancer Detection

Phase I Interventional United States

Bladder Cancer · Nerve Sheath Tumor · Nerve Sheath Tumors

Recruiting NCT07450599

A Study to Learn How Well a Combination of Darolutamide and Androgen Deprivation Therapy (ADT) Works as a Treatment Before Surgery for Men Who Have High-risk Localized Prostate Cancer.

Phase II Interventional China

High-Risk Localized Prostate Cancer

Not yet recruiting NCT07529080

Personalized Cancer Support (Thrive Track) to Manage the Emotional Needs of Young Adults With Thyroid, Melanoma and Testicular Cancer, PerCS-YA Trial

No phase Interventional United States

Differentiated Thyroid Gland Carcinoma · Malignant Testicular Neoplasm · Melanoma

Not yet recruiting NCT07659132

Fospropofol Disodium Versus Propofol for Patient Satisfaction in Ureteroscopy

Phase IV Interventional —

Anesthesia for Urologic Endoscopic Surgery · Urinary Calculi

Not yet recruiting NCT07661264

Effect of Different Pelvic Floor Loading Techniques on Women With Stress Urinary Incontinence

No phase Interventional Egypt

Stress Urinary Incontinence

Recruiting NCT06191731

Kinetics of Urinary Excretion of Gadolinium Contrast Agents Used in MRI Examinations

No phase Interventional France

Magnetic Resonance Imaging

Recruiting NCT07655050

Antibiotic Irrigation and Suction Ureteral Access Sheath in RIRS

No phase Interventional Turkey (Türkiye)

Kidney Calculi · Urolithiasis · Urinary Tract Infections

Not yet recruiting NCT07600216

A Multicenter, Randomized Controlled Superiority Trial Comparing Robotic-Assisted Versus Expert Cognitive Fusion Prostate Biopsy in Obese Men

No phase Interventional —

Prostate Biopsy

Not yet recruiting NCT07663968

Extracorporeal Shock Wave Therapy to Kegel's Exercise in Management of Female Stress Urinary

No phase Interventional —

Female Stress Urinary Incontinence

Recruiting NCT07336446

A Trial to Learn How Safe AZD9750 is and How Well it Works in People With Metastatic Prostate Cancer When Given With or Without Other Anticancer Drugs

Phase I / Phase II Interventional United States, Australia +6

Prostate Cancer

Recruiting NCT07216248

Optimal PSA Triggered Individual Management of Androgen Sensitive Prostate Cancer

Phase II Interventional United States

Metastatic Hormone-sensitive Prostate Cancer (mHSPC)

Not yet recruiting NCT07662863

Sacituzumab Tirumotecan vs MMAE-ADCs in Advanced Urothelial Carcinoma (FUSCC-SPARE-UC-01)

Phase II Interventional China

Bladder Cancer · Metastatic Urothelial Carcinoma · Urothelial Carcinoma

Recruiting NCT07202949

A Clinical Trial of Extended (High) Treatment Dose Antibiotics in Combination With Methenamine Hippurate Compared to the Standard of Care (Either Prophylactic (Low) Dose Antibiotic Treatment or Methenamine Hippurate) in Females With Chronic Urinary Tract Infection

Phase II Interventional United Kingdom

Chronic Urinary Tract Infection

Recruiting NCT04947254

Androgen Ablation Therapy With or Without Niraparib After Radiation Therapy for the Treatment of High-Risk Localized or Locally Advanced Prostate Cancer

Phase II Interventional United States

Prostate Carcinoma · Stage IIC Prostate Cancer AJCC v8 · Stage III Prostate Cancer AJCC v8

Recruiting NCT07662642

Timing of Recruitment Maneuver in Robotic Prostate Surgery

No phase Interventional Turkey (Türkiye)

Robotic Surgery · Urologic Surgical Procedures · Postoperative Pulmonary Complications (PPCs)

Recruiting NCT07463833

Artificial Intelligence (AI)-Enhanced Pretreatment Peer-review Process to Improve Patient Safety in Radiation Oncology

No phase Interventional United States

Cancer · Prostate Cancer

Recruiting NCT07206056

An Open-label Dose Escalation and Expansion, Followed by a Phase II Study of Tulmimetostat (DZR123) and JSB462 (Luxdegalutamide) in Patients With Progressive Metastatic Castrate Resistant Prostate Cancer (mCRPC) (TulmiSTAR-01)

Phase I / Phase II Interventional United States, Australia +12

Progressive Metastatic Castrate Resistant Prostate Cancer

Not yet recruiting NCT06702592

Virtual Testis Cancer Lay Support and Survivorship Aim 2

No phase Interventional United States

Testicular Cancer · Testis Cancer

Recruiting NCT07190300

TulmiSTAR-02: A Phase I/II Open-label Study of Tulmimetostat in Combination With Darolutamide vs. Darolutamide, and Tulmimetostat With Abiraterone in Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)

Phase I / Phase II Interventional United States, Australia +12

Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)

Not yet recruiting NCT06770855

Consolidative Metastasis and Primary Directed Therapy (MPDT) for Renal Cell Carcinoma (RCC)

No phase Interventional United States

Renal Cell Carcinoma

Recruiting NCT06533644

A Study of SYNC-T Therapy SV-102 in Participants With Metastatic Castration-Resistant Prostate Cancer

Phase II Interventional United States

Metastatic Castration-resistant Prostate Cancer

Recruiting NCT07074015

IntelliWell: An AI-Assisted Imaging Platform for Detection and Location of Ultra-Rare Testicular Sperm in Surgical Specimens

No phase Interventional United States

Infertility · Azoospermia

Not yet recruiting NCT07655284

STENT X: a Randomized Trial to Assess Stent-free Radical Cystectomy

Phase III Interventional United States, Brazil

Bladder Cancer Requiring Cystectomy · Ureteral Stents

Recruiting NCT00913939

High-Dose-Rate Brachytherapy

No phase Interventional Canada

Patients With Prostate Cancer

Enrolling by invitation NCT07660276

AI-based Prediction of Prostate Cancer Metastasis Using Biopsy Pathology

— Observational China

Prostate Cancer Metastatic

Not yet recruiting NCT07656701

Organizational Readiness And Barriers To Adoption Of Female External Urinary Devices In Hospitals

— Observational Egypt

Healthcare Technology Adoption · Organizational Readiness

Not yet recruiting NCT07657806

DEC003M in Prostate Cancer

Phase I Interventional China

Advanced Prostate Cancer

Not yet recruiting NCT07478536

Stockholm3 Test Validation in Men on Active Surveillance in Switzerland (CHAS3 Trial)

— Observational Switzerland

Prostate Cancer · Active Surveillance for Prostate Cancer

Enrolling by invitation NCT06674577

A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Atacicept

Phase II Interventional United States

IgA Nephropathy (IgAN) · Renal and Urinary Disorders · Berger Disease

Recruiting NCT04556916

Early Detection of Prostate Cancer

No phase Interventional France

Prostate Cancer

Recruiting NCT07660211

Clinical Evaluation of 177Lu-PSMA-VG01 Injection in Patients With PSMA-Positive Metastatic Castration-Resistant Prostate Cancer （mCRPC）

Phase I Interventional China

PSMA-positive Metastatic Castration-resistant Prostate Cancer (mCRPC)

Enrolling by invitation NCT07660068

HoLEP Sexual Survivorship

— Observational United States

BPH · Lower Urinary Tract Symptoms

Recruiting NCT07407582

Ph. I/II Sodium Thiosulfate for OtoProtection During Cisplatin (STOP-CIS)

Phase I / Phase II Interventional United States

Solid Tumor Malignancies · Testicular Cancer · Head and Neck Cancer

Recruiting NCT07484022

Study of GB-4362 With Enfortumab Vedotin and Pembrolizumab for Advanced Urothelial Cancer

Phase I Interventional United States

Advanced Urothelial Cancer · Metastatic Urothelial Carcinoma

Recruiting NCT04423211

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

Phase III Interventional United States

Biochemically Recurrent Prostate Carcinoma · Metastatic Prostate Carcinoma · Prostate Adenocarcinoma

Recruiting NCT07657325

Study on MRD Prediction of Efficacy of Toripalimab in the Treatment of High-risk Recurrent Renal Carcinoma

— Observational China

Renal Cell Carcinoma (RCC)

Recruiting NCT07635238

A Study of Lower Dose Radiation Therapy for People With Prostate Cancer

Phase II Interventional United States

Prostate Cancer · Prostate Adenocarcinoma

Not yet recruiting NCT07655830

Metabolic and Clinical Effects of Hyperchloremia During HoLEP Surgery.

— Observational —

HoLEP (Holmium Laser Enucleation of Prostate) · Hyperchloremia · Perioperative Management

Recruiting NCT02594202

Care of the Prostate Cancer Patient and Prospective Procurement of Prostate Cancer Tissue

— Observational United States

Prostate Cancer

Recruiting NCT06163469

Effect of Chlorhexidine Gluconate Bladder Instillations in Patients With Chronic Suprapubic Catheters on Unplanned Healthcare Encounters and Quality of Life

No phase Interventional United States

Neurogenic Bladder · Urinary Retention

Recruiting NCT05614739

FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3

Phase I Interventional United States, Australia +12

Urinary Bladder Neoplasms · Neoplasm Metastasis · Ureteral Neoplasms

Recruiting NCT06625034

Radiation Therapy With RapidPlan Knowledge-based Planning vs Human-Driven Planning for Treatment of Prostate Cancer

Phase III Interventional United States

Prostate Carcinoma

Not yet recruiting NCT07655713

Postoperative Urinary Retention Management in the Post Anesthesia Care Unit

— Observational —

Management of Post-operative Urinary Voiding Recovery in the Post-anesthesia Care Unit, Management of Post-opérative Urinary Retention

Recruiting NCT06922318

The COSMYC Trial (COmbined Suppression of MYC)

Phase II Interventional United States

Metastatic Castration-resistant Prostate Cancer

Recruiting NCT06990880

A Study of GSK5458514 Administered Alone or In Combination With Other Anti-Cancer Agents in Participants With Prostate Cancer

Phase I / Phase II Interventional United States, Canada +3

Neoplasms, Prostate

Recruiting NCT07111507

A Study of Tarlatamab for People With Prostate Cancer

Phase II Interventional United States

Metastatic Prostate Cancer

Recruiting NCT00969111

Postoperative or Salvage Radiotherapy (RT) for Node Negative Prostate Cancer Following Radical Prostatectomy

No phase Interventional United States

Prostate Cancer

Recruiting NCT07333066

Phase III Randomized International Open Label Clinical Trial of Treatment Intensification With Docetaxel Plus Apalutamide in Patients With Metastatic Hormone-sensitive Prostate Cancer Who Did Not Achieve a Deep PSA Response After Initial Treatment With Apalutamide: REINFORCE Trial.

Phase III Interventional France, Germany +3

Metastatic Hormone-sensitive Prostate Cancer

Enrolling by invitation NCT03456089

Measurement of Bladder Pressure With a Novel External Device, Comparison to Urodynamics Testing

No phase Interventional United States

Urinary Bladder, Neurogenic · Urodynamics

Recruiting NCT00033137

Genetic Analysis of Birt Hogg-Dube Syndrome and Characterization of Predisposition to Kidney Cancer

— Observational United States

Kidney Neoplasms · Kidney Cancer · Pneumothorax

Recruiting NCT07059858

Bladder and Bowel Functions, Participation and Quality of Life in Children With Intellectual Disabilities

— Observational Turkey (Türkiye)

Intellectual Disability · Healthy Subjects

Not yet recruiting NCT07224009

Low Dose Naltrexone (LDN) for Management of Fatigue in Prostate Cancer Patients on Androgen Deprivation Therapy (ADT)

Phase II Interventional —

Metastatic Prostate Cancer

Not yet recruiting NCT07650240

Study of PSMA-targeted Therapy and Androgen Receptor Suppression in Low-volume Metastatic ProstatE Cancer: SPARKLE Trial

Phase II Interventional United States

Recurrent Prostate Adenocarcinoma · Stage IVB Prostate Cancer AJCC v8 · Castration-Sensitive Prostate Cancer

Recruiting NCT04248283

Adjustable Continence Therapy (ACT) for the Treatment of Female SUI

No phase Interventional United States, France

Urinary Incontinence · Urinary Incontinence,Stress

Not yet recruiting NCT06769854

Defining the Safety and Efficacy of POSterIor Tibial NeRve StimulatiON in Children

Phase IV Interventional —

Overactive Bladder · Overactive Bladder Syndrome

Recruiting NCT07654413

Tamsulosin With or Without Tadalafil for Trial Without Catheter After Acute Urinary Retention Due to Benign Prostatic Hyperplasia

Phase IV Interventional Egypt

Acute Urinary Retention · Benign Prostatic Hyperplasia · Benign Prostatic Obstruction

Not yet recruiting NCT07645326

RISK-ADAPT Protocol in Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)

Phase II Interventional United States

Metastatic Hormone-sensitive Prostate Cancer (mHSPC)

Recruiting NCT07414849

The AMPER Study: Evaluation of the Efficacy of Human Amniotic Membrane Grafting in Preventing Mesh Exposure in Vaginal Reconstructive Surgery Using Polypropylene Mesh.

No phase Interventional Argentina

Pelvic Organ Prolapse Vaginal Surgery · Stress Urinary Incontinence in Women

Recruiting NCT06774131

A Phase 3 Single-arm Study of UGN-104 for the Treatment of Low-grade Upper Tract Urothelial Cancer

Phase III Interventional United States, Bulgaria +7

Upper Urinary Tract Urothelial Carcinoma · Urothelial Carcinoma

Recruiting NCT07548164

Comparing Two Different Boost Approaches in Radiation Therapy for People With Prostate Cancer

Phase III Interventional United States

Prostate Cancer

Recruiting NCT07642440

Suprapubic Drainage During Transurethral Cystolithotripsy for Large Bladder Stones

No phase Interventional Egypt

Bladder Stone · Cystolithiasis

Recruiting NCT06392295

PSMA-Directed Para-Aortic Radiation Therapy for Oligorecurrent Prostate Cancer

Phase II Interventional United States

Prostate Cancer · Prostate Adenocarcinoma · Hormone Sensitive Prostate Cancer

Not yet recruiting NCT07649122

This Study Evaluates the Diagnostic Performance and Safety of 68Ga-NYM032 PET/CT Imaging in Patients With Suspected Recurrence of Prostate Cancer.

Phase III Interventional —

Prostate Cancer

Recruiting NCT05790213

Prostate Cancer Treatment Using Androgen Deprivation Therapy and Focal Prostate Ablation

Phase II Interventional United States

Prostate Cancer

Recruiting NCT03547414

Does Urinary TIMP2 and IGFBP7 Can Identify High Risk Patients of Progression From Mild and Moderate to Severe Acute Kidney Injury During Septic Shock?

— Observational France

Acute Kidney Injury · Septic Shock

Not yet recruiting NCT07649421

PSMA PET/CT-Guided SBRT Plus Darolutamide in mHSPC

Phase II Interventional China

Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)

Recruiting NCT07650968

Tamsulosin Dose Escalation or Silodosin Switch Before Trial Without Catheter in BPH-Related Acute Urinary Retention

Phase IV Interventional Egypt

Acute Urinary Retention · Benign Prostatic Hyperplasia

Recruiting NCT07477626

Radiotherapy After Prostatectomy for Node Positive Prostate Cancer

Phase III Interventional China

Prostate Cancer (Post Prostatectomy) · Radiotherapy; Image-Guided · Prostate Cancer Non-Metastatic

Recruiting NCT07027124

Neoadjuvant ADT + Darolutamide With Pembrolizumab, Followed by Adjuvant Pembrolizumab in Molecularly Stratified High-Risk Prostate Cancer

Phase II Interventional United States

Prostate Cancer · High-risk Prostate Cancer

Recruiting NCT06202248

Alpha Radiation Emitters Device (DaRT) for the Treatment of Non-Metastatic Locally Recurrent Prostate Cancer.

No phase Interventional Israel

Non-metastatic Prostate Cancer · Locally Recurrent Prostate Cancer

Not yet recruiting NCT07124390

Electroacupuncture as a Treatment for Refractory Overactive Bladder

No phase Interventional United Kingdom

Over Active Bladder · Urinary Incontinence (UI) · Nocturia

Recruiting NCT07643415

Spinal Versus General Anesthesia in Open Simple Prostatectomy

No phase Interventional Turkey (Türkiye)

Urologic Neoplasms · Benign Prostatic Hyperplasia · Anesthesia

Recruiting NCT07038733

Investigation of Lymph Node Biology in Kidney Cancer

No phase Interventional United States

Renal Cell Carcinoma (RCC)

Recruiting NCT06942949

Evaluation of Enhanced Lithotripsy System (ELS) in the Treatment of Urinary Stones, A Pivotal Trial

No phase Interventional United States

Kidney Calculi; Ureteral Calculi

Recruiting NCT07648875

Water Vapor Thermal Therapy Versus Ejaculation-Preserving HoLEP for Benign Prostatic Hyperplasia

No phase Interventional Egypt

Benign Prostatic Hyperplasia · Lower Urinary Tract Symptoms

Recruiting NCT05422911

Abiraterone, Enzalutamide, or Apalutamide in Castrate-sensitive Prostate Cancer.

Phase II Interventional United States

Metastatic Cancer · Neoplasm, Prostate · Castrate-sensitive

Recruiting NCT04078373

Urinary Disorders in Subacute Patients After Stroke

— Observational Slovenia

Stroke, Ischemic · Stroke Hemorrhagic · Urinary Incontinence

Recruiting NCT03769766

Trial of Curcumin to Prevent Progression of Low-risk Prostate Cancer Under Active Surveillance

Phase III Interventional United States

Prostate Cancer

Recruiting NCT07416123

A Study of GEN1106 in Participants With Solid Tumors

Phase I Interventional United States, Japan +1

Solid Tumors · Urothelial Carcinoma

Recruiting NCT06434350

Enfortumab Vedotin With Radiation for Locally Advanced Bladder Cancer (CONSOLIDATE)

Phase I / Phase II Interventional United States

Advanced Bladder Cancer

Recruiting NCT05204186

Impact of COMORBIDities After Radical Cystectomy Using a Predictive Method With Artificial Intelligence

— Observational France

Bladder Cancer · Comorbidity · Deep Learning

Recruiting NCT06447103

An Investigational Scan (89Zr-DFO-GmAb PET/CT) Compared to Contrast-Enhanced CT for the Detection of Recurrent Clear Cell Renal Cell Cancer After Surgery Comparing Carbonic Anhydrase IX (CAIX) PET CT to Conventional PET CT for Post-Op Staging in Kidney Cancer

Phase II Interventional United States

Clear Cell Renal Cell Carcinoma · Sarcomatoid Renal Cell Carcinoma · Stage II Renal Cell Cancer

Recruiting NCT06956209

Akyva First In Human

No phase Interventional Australia

Underactive Bladder

Not yet recruiting NCT07635108

MR-guided Single-fraction SBRT for Nodal Oligorecurrent Prostate Cancer (PINPOINT)

No phase Interventional Denmark

Prostate Cancer · Oligo-metastatic Prostate Carcinoma · Oligometastatic Cancer

Recruiting NCT07648888

Water Vapor Thermal Therapy Versus Ejaculation-Sparing Bipolar Transurethral Enucleation for Benign Prostatic Hyperplasia

No phase Interventional Egypt

Benign Prostatic Hyperplasia · Lower Urinary Tract Symptoms · Ejaculatory Dysfunction