GI & liver — clinical trials

Clinical Stage III Gastric Cancer AJCC v8 · Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 · Clinical Stage IV Gastric Cancer AJCC v8

Recruiting NCT06338332

Obstructive Colon Cancer, a Bridge to Surgery in Right Sided Obstructive Colon Cancer

— Observational Netherlands

Colonic Neoplasms Malignant

Not yet recruiting NCT06337773

Developing the Precision Nursing Education Program to Young Colorectal Cancer Survivors

No phase Interventional —

Depression

Not yet recruiting NCT06335576

Establishment of Serum Proteomics Subtypes of Gastric Cancer and Its Clinical Application

— Observational —

Gastric Cancer

Recruiting NCT06145074

Examining Safety, Efficacy and Feasibility of Preoperative Propranolol in Patients With PDAC.

Phase II Interventional Denmark

Pancreatic Cancer · Surgery

Recruiting NCT06331988

Microbiome, Immune-system and Tumor Interaction in Colorectal Cancer

— Observational Italy

Colorectal Cancer

Recruiting NCT06326502

A Safety and Efficacy Study of Multiple Tyrosine Kinase Inhibitor Drug (ETN101) in Advanced Hepatocellular Carcinoma

Phase I Interventional South Korea

Hepatocellular Carcinoma · Advanced Hepatocellular Carcinoma · Liver Cancer

Not yet recruiting NCT06331260

Assessment of AFP and PIVKA-II as Prognostic Indicators in Liver Transplantation for Hepatocellular Carcinoma

— Observational —

Liver Transplantation · Hepatocellular Carcinoma · Alpha-Fetoprotein

Not yet recruiting NCT06331273

Impact of "No-touch" Technique on the Outcome of Liver Transplantation for Hepatocellular Carcinoma

— Observational —

Liver Transplantation · No-touch Technique · Hepatocellular Carcinoma

Recruiting NCT06326879

A Comparative Study Between Early Onset Colorectal Cancer and Late Onset Colorectal Cancer Patients

— Observational Italy

Colorectal Cancer

Not yet recruiting NCT06243887

Implementing Enhanced Recovery After Surgery (ERAS) Protocol in Patients Undergoing Minimal Invasive Esophagectomy

No phase Interventional —

Esophageal Diseases · Esophagostomy Complication

Recruiting NCT06326736

Study of Neoantigen mRNA Vaccines in Patients With Resectable Pancreatic Cancer

Early Phase I Interventional China

Pancreatic Cancer

Recruiting NCT06162767

Cancer of Esophagogastric Junction: Optimized Sweet Versus Ivor-Lewis

No phase Interventional China

Esophagogastric Junction Carcinoma

Recruiting NCT05093881

Long-term Follow-up of Patients With Alcoholic Liver Cirrhosis Who Had Administered Cellgram-LC in PMC-P-07 Study

No phase Interventional South Korea

Alcoholic Cirrhosis

Not yet recruiting NCT06322225

Establishment of Big Data Platform and Biobank for Colorectal Tubular Adenoma Lesions

— Observational —

Colorectal Tubular Adenoma

Recruiting NCT06196788

Transcatheter Arterial Infusion to Patients With Advanced Pancreatic Cancer

Phase II Interventional China

Pancreatic Cancer

Recruiting NCT06265025

GM103 Intratumoral Injection in Patients With Locally Advanced, Unresectable, Refractory and/or Metastatic Solid Tumors

Phase I / Phase II Interventional South Korea

Head and Neck Cancer · Malignant Melanoma · Colorectal Cancer

Not yet recruiting NCT06317896

Value of Dynamic Monitoring of Early Recurrence of Hepatocellular Carcinoma After Radical Resection Based on CTCS

— Observational China

Hepatocellular Carcinoma · Circulating Tumor Cell · Recurrence

Recruiting NCT05883800

Total Neoadjuvant Treatment Combined With Adaptive Radiotherapy for Rectal Cancer

No phase Interventional Norway

Rectal Cancer

Recruiting NCT05224518

Exercise Intervention to Improve Quality of Life in Patients With Colorectal Cancer

No phase Interventional Taiwan

Colorectal Cancer · Fatigue · Quality of Life

Recruiting NCT06234007

Short-course Radiotherapy Followed by Fruquintinib Plus Adebrelimab and CAPOX in the Full Course Neoadjuvant Treatment of Locally Advanced Rectal Cancer: a Multicenter, Single-arm, Open-label Study

Phase II Interventional China

Locally Advanced Rectal Cancer

Recruiting NCT06310902

Single-cell Sequencing Analysis of Resectable/Borderline Resectable Pancreatic Cancer Patients

— Observational China

Pancreatic Neoplasms

Not yet recruiting NCT06259058

Stereotactic Body Radiation Therapy Followed by NALIRIFOX vs NALIRIFOX for Borderline Resectable Pancreatic Cancer

Phase I / Phase II Interventional —

Pancreatic Cancer

Recruiting NCT06308757

Role of the Very Low Calorie Ketogenic Diet (VLCKD) in Patients With Non-Alcoholic Steatohepatitis (NASH) With Fibrosis

No phase Interventional Italy

NASH · NAFLD · Obesity

Recruiting NCT06302751

A Mobile Application to Improve Postoperative Outcomes in Colorectal Cancer

No phase Interventional Italy

Colorectal Cancer · Surgery

Not yet recruiting NCT06310473

Neoadjuvant Cadonilimab Plus Chemotherapy for Locally Advanced Esophagogastric Junction and Gastric Cancer Trial

Phase II Interventional China

Gastric Cancer · Esophagogastric Junction Cancer

Not yet recruiting NCT06313554

Surufatinib Combined With Toripalimab and HAIC in the Treatment of Inoperable or Metastatic Intrahepatic Cholangiocarcinoma

No phase Interventional —

Intrahepatic Cholangiocarcinoma

Recruiting NCT06304350

Pembrolizumab Combined With Preoperative Chemotherapy (Albumin Paclitaxel+Carboplatin) Neoadjuvant Therapy for Resectable Locally Advanced (Stage II/III) Esophageal Squamous Cell Carcinoma

Phase II Interventional China

Esophageal Cancer

Recruiting NCT03811236

Cold-induced Brown Fat Activation and Hepatic Steatosis

No phase Interventional Austria

Non-Alcoholic Fatty Liver Disease

Not yet recruiting NCT05473403

Validation of a Prognostic Score for Steroid Therapy Response in Acute Severe Autoimmune Hepatitis

No phase Interventional France

Liver Failure, Acute · Hepatitis, Autoimmune · Organ Dysfunction Scores

Recruiting NCT06185244

Efficacy of Internet-delivered Trauma-focused CBT for Young People With PTSD

No phase Interventional Sweden

Posttraumatic Stress Disorder

Recruiting NCT06308354

Colorectal Cancer Dataset in Xijing Hospital From 2011

— Observational China

Prognostic Cancer Model · Chemotherapy · Nutrition Related Cancer

Recruiting NCT03851627

Effects of Testosterone Undecanoate vs Placebo on Intrahepatic Fat Content in Overweight/Obese Men With T2DM or Prediabetes and Hypogonadism

Phase IV Interventional Austria

Fatty Liver · Overweight/Obesity · Prediabetes/Type2 Diabetes Mellitus

Enrolling by invitation NCT06303583

Neoadjuvant Chemoradiotherapy Followed by Sequential Immunotherapy for Thoracic Esophageal Squamous Cell Carcinoma

Phase I / Phase II Interventional China

Esophageal Squamous Cell Carcinoma

Recruiting NCT05170971

Fecal Microbiota Transplantation for Liver Failure

No phase Interventional China

Liver Failure

Recruiting NCT06261125

Combination of SBRT, PD-L1 Inhibitor, and Lenvatinib in Hepatocellular Carcinoma (HSBRT2401)

Phase II Interventional China

Hepatocellular Carcinoma

Recruiting NCT05975749

Adjuvant Serplulimab and Trastuzuma and Chemotherapy in Her-2+ Gastric Cancer

Phase II Interventional China

Gastric Cancer

Not yet recruiting NCT06306781

A Clinical Trial Evaluating the Safety, Tolerability, and Preliminary Efficacy of HCL001 Cell Injection (Homologous Allogeneic Hepatocytes) in Patients With Decompensated Cirrhosis

No phase Interventional —

Decompensated Cirrhosis

Recruiting NCT06187597

Consolidation of Toripalimab After Chemoradiotherapy in Elderly Esophageal Cancer (EC-CRT-007)

Phase II Interventional China

Locally Advanced Esophageal Squamous Cell Carcinoma

Not yet recruiting NCT06304545

Treatment of Rectal Cancer With Long-term Concurrent Chemoradiotherapy Combined With Camrelizumab

Phase II Interventional —

Rectal Cancer

Enrolling by invitation NCT04793633

Evaluating LINFU™: A Noninvasive Method for Collecting Pancreatic Cells for the Early Detection of Pancreatic Cancer

— Observational United States

Pancreatic Ductal Adenocarcinoma

Recruiting NCT06302335

Povidone-iodine vs Saline Solution in Colorectal Surgeries and Its Effects on the Surgical Site Infection

Phase III Interventional Brazil

Surgical Site Infection

Recruiting NCT04455282

CIRCULATing Biomarkers for Individualized Surgical Therapy in gastroEsophageal Cancer - Phase 1

— Observational Germany

Cancer of Esophagus · Esophagogastric Junction Disorder

Not yet recruiting NCT06301386

Everolimus Combined With PD-1 in Advanced Colorectal Cancer Patients

Phase II Interventional China

Colon Cancer

Recruiting NCT06194734

A Study of KC1036 Versus Investigator's Choice of Chemotherapy in Patients With Advanced Esophageal Cancer

Phase III Interventional China

Esophageal Squamous Cell Carcinoma

Not yet recruiting NCT06253598

Efficacy and Safety of Intratumoral Injection of Recombinant Human Adenovirus Type 5 Combined With Tislelizumab and Lenvatinib in the Treatment of Advanced Hepatocellular Carcinoma

Phase II Interventional —

Hepatocellular Carcinoma

Not yet recruiting NCT06295094

The Efficacy of PIPAC and Minimally Invasive Radical Resection in High-risk Gastric Cancer Patients.

Phase II Interventional United States, Denmark +3

Gastric Cancer · Chemotherapy, Adjuvant · Peritoneal Metastases

Recruiting NCT04597294

Prophylactic Preoperative HIPEC in Advanced Gastric Cancer at High Risk of Peritoneal Recurrence

Phase III Interventional Poland

Gastric Cancer

Recruiting NCT06293014

TAS-102 Combined With Bevacizumab for Second-line Maintenance Treatment of Advanced Colorectal Cancer

Phase II Interventional China

Colorectal Cancer

Recruiting NCT06275204

H. Pylori Screen-and-treat Study in a Population of Young Adults

— Observational Croatia, Ireland +4

Gastric Cancer · H Pylori Infection · H Pylori Eradication

Not yet recruiting NCT06279845

A Clinical Cohort Study on the Pathogen Spectrum of Hepatic Virus-caused Cirrhosis Complicated With Infection

— Observational —

Liver Cirrhosis

Not yet recruiting NCT06272071

A Multicenter Prospective Clinical Cohort Study on the Pathogen Spectrum of Severe Hepatitis (Liver Failure) Complicated With Infection

— Observational —

Liver Failure

Not yet recruiting NCT06279884

A Cohort Study on the Pathogen Spectrum of Liver Transplant Recipients Complicated With Infection

— Observational —

Liver Transplantation · Transplant Recipients

Not yet recruiting NCT06283121

A Clinical Study of BioTTT001 in Combination With SOX and Toripalimab in Patients With Gastric Cancer

Phase II Interventional —

Gastric Cancer, Metastatic

Recruiting NCT05970666

Single Arm, Prospective, Multicenter Clinical Study of TACE With Adebrelimab and Bevacizumab for Unresectable Hepatocellular Carcinoma

Phase II Interventional China

Adebrelimab · Hepatocellular Carcinoma · Transformation

Not yet recruiting NCT06233877

Clinical Trial Evaluating Low Dose G-FLIP Plus Mitomycin C for Stage IV Pancreatic Cancer

Phase II Interventional United States

Pancreatic Cancer

Recruiting NCT01935778

Compare Adjuvant Chemotherapy of Docetaxel/Capecitabine/Oxliplatin Versus Capecitabine/Oxaliplatin in Advanced Gastric Cancer at Stage IIIb and IV(KCSG ST15-08): TRIUMPH

Phase III Interventional South Korea

Gastric Cancer, Adjuvant Chemotherapy, XO

Not yet recruiting NCT06276153

Construction of Multicenter Retrospective Registry Cohort Database for Gallbladder Cancer

— Observational —

Biliary Tract Diseases · Gallbladder Cancer · Gallbladder Neoplasms

Recruiting NCT02454790

Standard Follow-Up Program (SFP) for Patients With Esophageal Cancer

— Observational Netherlands

Esophageal Cancer

Recruiting NCT06177041

M108 Plus CAPOX Versus Placebo Plus CAPOX as First-line Treatment for Claudin (CLDN) 18.2-Positive, HER2-Negative, PD-L1 CPS<5, Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma.

Phase III Interventional China

Locally Advanced Unresectable or Metastatic Gastric Cancer · Locally Advanced Unresectable or Metastatic Gastroesophageal Junction (GEJ) Adenocarcinoma

Recruiting NCT06279299