GI & liver — clinical trials

Recruiting NCT07006467

Initial Feasibility Study of the STENTiT Resorbable Fibrillated Scaffold (RFS). The RFS is Intended to Restore Lumen Patency and Blood Flow to Infrapopliteal Arteries. The RFS is a Fully Electrospun Tubular Device With a Fibrillated Microarchitecture and Designed for Transcatheter Delivery

No phase Interventional Austria

Critical Limb Ischemia (CLI)

Recruiting NCT07056010

Efficacy and Safety of Minimally Invasive D2+PAND Gastrectomy for Gastric Cancer With PAN Metastasis After Conversion Immunochemotherapy

No phase Interventional China

Gastric Cancer

Not yet recruiting NCT07055490

Interdisciplinary Practice Bundle for Second-Stage of Labor and Clinical Outcomes

No phase Interventional —

Delivery Outcomes

Recruiting NCT06848400

Capsule Gastric Endoscopy for Gastric Disease Screening in Simulated Home Scenarios

No phase Interventional China, Hong Kong +1

Gastric Lesion · Gastritis · Upper Gastrointestinal Bleeding (UGIB)

Recruiting NCT07056374

Adaptive Anastomosis for Anterior Resection in Sigmoid and Proximal Rectal Cancer or Premalignant Lesions

— Observational Netherlands

Rectal Cancer · Sigmoid Cancer · Premalignant Lesion

Recruiting NCT07054879

CtDNA-guided Maintenance Therapy in Pancreatic Cancer

— Observational China

Pancreatic Cancer

Not yet recruiting NCT07049315

Mandibular Advancement Devices for Reflux in Obstructive Sleep Apnea

Phase III Interventional Brazil

Gastroesophageal Reflux Disease

Recruiting NCT06846996

Real-world Effectiveness and Safety of Trastuzumab Deruxtecan in Patients With Locally Advanced or Metastatic HER2-positive Gastric or Gastroesophageal Junction Adenocarcinoma in China

— Observational China

HER2-positive Gastric Cancer · HER2-positive Gastroesophageal Junction

Recruiting NCT07054086

Patient Derived Organoids (PDOs) to Observe the Clinical Consistency of Personalized Neoadjuvant Therapy for Resectable Esophageal Squamous Cell Carcinoma

— Observational China

Esophageal Cancer

Recruiting NCT07053488

CRISPR-Edited HLA Donor Liver Transplant to Reduce Rejection

Phase I / Phase II Interventional China

Liver Diseases · Liver Cancer · Liver Cirrhosis

Recruiting NCT06149546

Exploring the Impact of a Multi-modal Nutritional Intervention in Patients Undergoing Chemotherapy for Pancreatic Cancer (FEED Trial)

No phase Interventional Ireland

Pancreatic Cancer

Recruiting NCT07049159

Safety, and Efficacy Study of ShigETEC, a Live, Attenuated, Oral Combination Vaccine to Prevent Shigella and ETEC Disease Delivered to Healthy Adults Ages 18 to 50 Years Old

Phase II Interventional United States

Shigella

Not yet recruiting NCT07055048

The Diagnostic Efficacy and Lesion Detection Advantages of 18F-FDG PET/Contrast-enhanced MRI in Malignant Liver Lesions

— Observational —

Liver Cancer, Adult

Not yet recruiting NCT07053332

A Study on Immunotherapy Combined With Radiotherapy for Esophagogastric Junction/Gastric Adenocarcinoma

Phase II Interventional —

Esophagogastric Junction/Gastric Adenocarcinoma

Recruiting NCT06896643

Urinary Infection and Colonization in Bone Procedures

— Observational Czechia

Urinary Tract Infection · Complications · Urinary Tract Infection (Diagnosis)

Not yet recruiting NCT07054047

Improving Diagnosis and Treatment for Patients With Rectal Cancer

No phase Interventional United Kingdom

GI Cancer

Recruiting NCT06092385

SASL Swiss Cirrhosis Cohort

— Observational Switzerland

Liver Cirrhosis

Recruiting NCT07032961

A Cohort Study of Mobile Capsule Gastroscopy for Gastric Pathologies Screening

— Observational China

Gastritis · Gastric Dysplasia · Gastric Ulcer

Recruiting NCT05797805

A Study of Tegavivint (BC2059) in Patients With Advanced Hepatocellular Carcinoma

Phase I / Phase II Interventional United States, Canada

Advanced Hepatocellular Carcinoma

Recruiting NCT06911619

Impact of Nutritional Management on the Frailty of Patients Waiting for Liver Transplantation (Via the LFI Tool)

No phase Interventional France

Fragility · Cirrhosis · Hepatic Transplantation

Enrolling by invitation NCT07052448

The Efficacy of Sequential RT After Triple Therapy for uHCC

— Observational China

Hepatocellular Carcinoma

Not yet recruiting NCT07051785

Fruquintinib vs Bevacizumab Combined With Irinotecan Liposome and Capecitabine as Second-Line Therapy for Advanced Metastatic Colorectal Cancer

Phase II Interventional —

Colorectal Cancer (CRC)

Not yet recruiting NCT07050524

Omega-3 Supplementation and Immunotherapy in Gastric Cancer: A Phase II Trial

Phase II Interventional China

Gastric Cancer Stage III

Recruiting NCT04958720

Spanish Registry of Esophagogastric Cancer

— Observational Spain

Esophageal Cancer · Gastric Cancer

Recruiting NCT07050550

A Prospective Study of ¹⁸F-DFA PET Imaging for the Assessment of Liver Injury

— Observational China

Liver Injury

Recruiting NCT05860569

Safety Evaluation of Gene Therapy Drug in the Treatment of Primary Hypertriglyceridemic Patients With Recurrent Pancreatitis

Phase I Interventional China

Hypertriglyceridemia, Familial

Recruiting NCT05789433

Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer

No phase Interventional United States

Colonic Neoplasms · Rectal Neoplasms

Recruiting NCT07050394

A Dose-Expansion Trial of Intravenous HNF4α srRNA for Unresectable or Metastatic Colorectal Cancer

Early Phase I Interventional China

Colorectal Cancer Metastatic · Colorectal Cancer Recurrent · Colorectal Cancer Stage IV

Recruiting NCT07047586

Lenvatinib Plus Tislelizumab Versus Lenvatinib Alone in Hepatocellular Carcinoma Previously Treated With Anti-PD1/PD-L1 and Bevacizumab

Phase II Interventional China

Hepatocellular Carcinoma (HCC)

Not yet recruiting NCT07049185

QL1706 Plus Celecoxib in Advanced Esophageal Squamous Cell Carcinoma

Phase II Interventional —

Esophageal Squamous Cell Carcinoma

Recruiting NCT06630624

Dose Finding, Efficacy and Immunological Response of IP-001 Following MWA or IRE for CRLM

Phase I / Phase II Interventional Netherlands

Colorectal Cancer · Liver Metastases · Liver Metastasis Colon Cancer

Not yet recruiting NCT07049146

Efficacy and Safety of Contrast EUS-Guided Tissue Glue/Coil Devascularization vs. BRTO for Preventing Recurrent Gastric Variceal Bleeding

No phase Interventional China

Gastric Varices Bleeding

Not yet recruiting NCT07050030

Association of Preoperative Coronary Calcium Score and Postoperative Atrial Arrythmia in Patients Undergoing Robot-assisted Esophagectomy: Prospective Observational Study

— Observational South Korea

Patients Undergoing Robot-assisted Esophagectomy

Recruiting NCT07050576

Lymph Node Metastasis in Early Esophageal Squamous Cell Carcinoma

— Observational China

ESCC · Lymph Node Metastasis · Radiomics

Recruiting NCT06365424

Fenofibrate in Patients With Primary Biliary Cholangitis (PBC)

Phase II / Phase III Interventional China

Primary Biliary Cholangitis

Recruiting NCT06978114

A Study of BL-B01D1+PD-1/PD-L1 Monoclonal Antibody in Patients With Advanced Biliary Tract Cancer

Phase II Interventional China

Advanced Biliary Tract Cancer

Recruiting NCT06687291

Cognitive Impact Associated With Surgery For Gastric Or Esophageal Cancer

— Observational Sweden

Gastroesophageal Cancer (GC) · Postoperative Delirium (POD) · Quality of Life (QOL)

Recruiting NCT06954467

JS207 Combined With JS007 as First-line Treatment for Advanced Hepatocellular Carcinoma

Phase II Interventional China

Hepatocellular Carcinoma

Enrolling by invitation NCT07047937

Explainable Machine Learning for Predicting Early Gastric Cancer

— Observational China

Early Gastric Cancer

Recruiting NCT06893887

Individualized Comprehensive Treatment for Advanced Hepatocellular Carcinoma

No phase Interventional China

Hepatocellular Carcinoma(HCC)

Recruiting NCT06964425

Raman Spectroscopy in the Diagnosis of Extrahepatic Cholangiocarcinoma - a Pilot Study

No phase Interventional Czechia

Cholangiocarcinoma, Extrahepatic · Cholangiocarcinoma of the Extrahepatic Bile Duct · Cholangiocarcinoma, Perihilar

Recruiting NCT06076889

Power Over Pain Portal: A Stepped-care Virtual Solution to Deliver Early Intervention to Canadian Youth With Chronic Pain

— Observational Canada

Chronic Pain

Recruiting NCT06999174

Multiparametric MRI for Characterization of Hepatocellular Carcinoma

— Observational Germany

Hepatocellular Carcinoma (HCC)

Recruiting NCT07047560

Liposomal Irinotecan (II) Fractionated Dosing Combined With 5-FU/LV (FOLFIRInali-3) and Bevacizumab in Second-line Treatment of Advanced Colorectal Cancer: A Single-arm, Phase II Clinical Study

Phase II Interventional China

Colorectal Cancer (CRC)

Enrolling by invitation NCT07046832

Clinical Evaluation of an Augmented Reality Intraprocedural Needle Guidance Platform for Soft Tissue Biopsy

No phase Interventional United States

Oncology · Interventional Radiology · Liver Carcinoma

Not yet recruiting NCT07045558

HAIC + Atezolizumab Plus Bevacizumab in Unresectable HCC

— Observational China

Unresectable Hepatocellular Carcinoma

Not yet recruiting NCT07045805

Phase II Study of QL1706 Combined With Paclitaxel and Bevacizumab for Second-Line Immune Rechallenge in Gastric Cancer

Phase II Interventional —

Gastric Cancer (GC)

Not yet recruiting NCT07028424

PANORAMIX : Optimizing 1st-line NALIRIFOX and Exploring Microbiota's Role in 2nd Line Pancreatic Cancer Treatment

Phase II Interventional France

PDAC - Pancreatic Ductal Adenocarcinoma

Recruiting NCT06585072

Pancreatic Cancer and Diabetes Mellitus

— Observational China

Pancreatic Cancer · Surgery · Diabetes Mellitus

Recruiting NCT06957626

Development and Validation of Microbiota and Metabolite-based Prediction Model for Recurrence of High-risk Colorectal Polyps After Polypectomy

— Observational China

Colorectal Polyp · Colorectal Cancer Recurrent · Colorectal Adenoma

Not yet recruiting NCT07012694

22G-Adapt vs 22G-Franseen Needle Biopsy in EUS-Guided Tissue Acquisition of Solid Lesions

No phase Interventional China

Pancreatic Neoplasms · Mediastinal Neoplasms · Abdominal Neoplasm, Excluding Pancreas Neoplasm

Not yet recruiting NCT07045207

Evaluating AI and Human Expert Decisions in Colorectal Cancer

— Observational China

Colorectal Cancer

Recruiting NCT07045571

MSCAN: ctDNA Methylation as Prognostic and Theranostic Tool for Pancreatic Cancer

— Observational China

Pancreatic Neoplasm · Pancreas Cancer

Recruiting NCT07044921

Clinical Study of Irinotecan Liposome (II)-Based Combination Treatment for Irinotecan-resistant Colorectal Cancer.

Phase II Interventional China

Colorectal Cancer Metastatic

Recruiting NCT05310643

Nivolumab and Ipilimumab in Anti-PD1-Resistant dMMR/MSI mCRC

Phase II Interventional France

Metastatic Colorectal Cancer

Recruiting NCT06895447

Robotic Gastrectomy for Locally Advanced Gastric Cancer After Neoadjuvant Therapy

Phase II Interventional China

Gastric Cancers

Enrolling by invitation NCT07042841

AI-Driven Quantitative Decision and Surgical Planning System for Liver Cancer

— Observational China

Liver Cancer, Adult

Recruiting NCT07042308

Natural History of Advanced Chronic Liver Diseases

— Observational Hong Kong

Cirrhosis · Advanced Chronic Liver Disease

Not yet recruiting NCT06776146

Proteomic Profiling to Differentiate Pancreatic and Biliary Adenocarcinomas

— Observational France

Pancreatic Adenocarcinoma

Recruiting NCT07033156

An Exploratory Study on Gene Methylation Detection of Colorectal Cancer

— Observational China

CRC (Colorectal Cancer) · Adenoma Colon

Recruiting NCT07043491

Comparison of Endoscopy and Esophagram for the Routine Evaluation of Anastomosis After McKeown Esophagectomy

— Observational China

Esophageal Cancer · Surgery-Complications

Not yet recruiting NCT07036627

Intestinal Microbiota After PPI Treatment

— Observational Italy

Proton Pump Inhibitors · Human Gastrointestinal Tract · Gastroesophageal Reflux Disease

Recruiting NCT07036874

Non-invasive Assessment for Outcome Prediction in Patients With Hepatocellular Carcinoma

— Observational Hong Kong

HCC - Hepatocellular Carcinoma · Cirrhosis

Not yet recruiting NCT06780553

Validation of the Proteomic Profiling as a Diagnostic Test for Extra-hepatic Cholangiocarcinoma

— Observational France

Cholangiocarcinoma

Not yet recruiting NCT07041515

Knowledge-enhanced Digital Intervention to Prevent Low Anterior Resection Syndrome

No phase Interventional —

Rectal Neoplasm

Recruiting NCT05663775

Prophylactic Mesalamine to Prevent Colitis Following Treatment With Ipilimumab/Nivolumab (Ipi/Nivo)

Phase II Interventional Canada

Immune-related Adverse Event · Diarrhea · Advanced Melanoma

Recruiting NCT05339984

Hepatic and Systemic Hemodynamic Modeling During Liver Surgery

No phase Interventional France

Liver Diseases · Liver Transplantation

Not yet recruiting NCT04901741

Olaptesed With Pembrolizumab and Nanoliposomal Irinotecan or Gemcitabine/Nab-Paclitaxel in MSS Pancreatic Cancer

Phase II Interventional —

Metastatic Pancreatic Cancer

Recruiting NCT07041255

Comparison of Cold and Hot Loop Resection Techniques for the Removal of Medium-sized Benign Colon Tumors

No phase Interventional Russia

Benign Colon Tumors

Not yet recruiting NCT06823297

Can Neoadjuvant Chemoradiotherapy be Ommited in Mid-rectal Cancer

— Observational Turkey (Türkiye)

Mid-Rectal Cancer · Rectal Cancer Stage II · Rectal Cancer Stage III

Enrolling by invitation NCT07041229

Comparison of Methods for Removing Large Benign Broad-based Epithelial Neoplasms of the Colon: ESD and EMR.

No phase Interventional Russia

Benign Colon Tumors

Recruiting NCT05727722

Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure Adults

Phase I Interventional China

Acute-On-Chronic Liver Failure · Chronic Liver Failure

Recruiting NCT05863208

Artificial Intelligence-assisted Colonoscopy With or Without Endocuff Vision

No phase Interventional Taiwan

Adenoma Detection Rate

Not yet recruiting NCT06194461

LTFU for All Cell and Gene Therapy Studies

— Observational United States, Australia +2

Hepatocellular Carcinoma · Prostate Cancer

Recruiting NCT05775146

SBRT of Metastases Following Neo-adjuvant Treatment for Colorectal Cancer With Synchronous Liver Metastases

Phase II Interventional Canada

Colorectal Cancer · Liver Metastasis Colon Cancer

Recruiting NCT06825546

Icaritin in Combination With AG in Patients With Previously Untreated Advanced Pancreatic Ductal Adenocarcinoma

Phase II Interventional China

Advanced Pancreatic Ductal Adenocarcinoma

Recruiting NCT05035108

The Treatment of Bioartificial Liver With hiHep Cells After Extensive Hepatectomy

Early Phase I Interventional China

Hepatoma Resectable

Recruiting NCT07040098

Optimizing Immunotherapy Combined With Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer

Phase II Interventional China

Locally Advanced Rectal Cancer (LARC)

Recruiting NCT06643208

D-TACE-HAIC Combined With Envafolimab and Lenvatinib for Unresectable ICC

— Observational China

Intrahepatic Cholangiocarcinoma

Recruiting NCT07038148

Exploring the Efficacy of Single-stage Stapled Conversion of Gastric Bypass to Sleeve Gastrectomy, More Leak?

No phase Interventional Egypt

the Focus of the Study is to Assees Efficacy of Stapled Revision of Gastric Bypass to Sleeve Gastrectomy

Not yet recruiting NCT07038863

Community Screening and Management of Hepatitis B, C and Delta in the Mongolian Population Living in France

No phase Interventional France

HEPATITIS C (HCV) · Hepatitis B Virus (HBV) · Hepatitis D

Recruiting NCT05451043

Durvalumab and Tremelimumab in Combination With Propranolol and Chemotherapy for Treatment of Advanced Hepatopancreabiliary Tumors (BLOCKED)

Phase II Interventional Canada

Pancreatic Cancer · Hepatocellular Cancer · Biliary Tract Cancer

Not yet recruiting NCT07035600

Walking and Sitting Difficulties After Rectal Cancer Surgery

No phase Interventional Sweden

Rectal Cancer Patients · Rectal Cancer Surgery · Rectal Cancer, Radiotherapy

Recruiting NCT06517225

Visual-acoustic Intervention With Service Delivery In-person and Via Telepractice Trial

Phase II Interventional United States

Speech Sound Disorder

Recruiting NCT06328517

The Influence of Nutritional Factors on the Prognosis of Liver Cirrhosis Patients and the Exploration of Predictive Models

— Observational China

Cirrhosis

Recruiting NCT06081647

The Efficacy and Safety of the COMBO Endoscopy Oropharyngeal Airway in Gastrointestinal Endoscopy Procedure

No phase Interventional China

Hypoxia · Gastric Polyp · Colon Cancer

Recruiting NCT05561114

Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Esophagus

Phase III Interventional United States

Esophageal Stricture

Recruiting NCT07012954

ctDNA-Guided Cetuximab or Bevacizumab Plus Trifluridine/Tipiracil in RAS/BRAF Wild-Type mCRC

Phase I / Phase II Interventional China

Colorectal Cancer Metastatic

Recruiting NCT07032974

RCT Comparing Accuracy Among Franseen, Forward-bevel Westcott, and Fork-tip EUS-FNB Needle in Diagnosis of Solid Pancreatic Lesions

No phase Interventional Thailand

Pancreatic Masses

Not yet recruiting NCT06902701

Endoscopic Submucosal Dissection vs. Transanal Endoscopic Surgery for Rectal Neoplasia

— Observational Turkey (Türkiye)

Rectal Neoplasms

Enrolling by invitation NCT07023471

Artificial Intelligence-assisted Colonoscopy, Tandem Study

No phase Interventional Thailand

Artificial Intelligence (AI) · Colonoscopy Education · Adenoma Colon Polyp

Recruiting NCT06885385

A Phase 2 Study Evaluating the Safety and Efficacy of JS207 With or Without JS015 in Combination With Chemotherapy in Patients With Colorectal Cancer

Phase II Interventional China

Advanced Colorectal Cancer

Not yet recruiting NCT07034118

Definitive Proton Radiotherapy Combined With Chemotherapy and Immunotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma: A Phase I Clinical Study

Phase I Interventional China

Esophageal Carcinoma

Not yet recruiting NCT07034703

Prospective Cohort of Patients Treated Using Neoadjuvant Modified FOLFIRINOX 6 Cycles for Potentially Resectable Pancreatic Duct Adenocarcinoma, Candidate for Participation in the PANACHE02 Clinical Trial

— Observational France

Resectable Pancreatic Duct Adenocarcinoma

Recruiting NCT06769425

HS-10502 Combination Treatment in Patients With Advanced Solid Tumors

Phase I Interventional China

Recurrent Ovarian Cancer · HER2-negative · Advanced Breast Cancer

Recruiting NCT07035002

Study on the Safety and Tolerability of PD-1 Knockout Tumor-infiltrating T Cells (TILs) in the Treatment of Advanced Colorectal Cancer

Phase I Interventional China

Colorectal Cancer (CRC) · Tumor Infiltrating Lymphocytes · PD-1

Not yet recruiting NCT07033143

Evaluation of the Efficacy and Safety of Adebrelimab Combined With SOX as Adjuvant Therapy for IIIB and IIIC Gastric Cancer

Phase II Interventional —

Gastric Cance

Recruiting NCT07012772

COMBO Endoscopy Oropharyngeal Airway in Sedated Endoscopic Retrograde Cholangiopancreatography for Patients

Phase II Interventional China

Choledocholithiasis With Cholecystitis With Obstruction · Obstructive Jaundice · Pancreatitis

Not yet recruiting NCT06943768

Fecal DNA Methylation and Helicobacter Pylori Gastric Cancer Susceptibility Genes Test

— Observational —

Gastric (Stomach) Cancer

Enrolling by invitation NCT06987604

Continuous Renal Replacement Therapy Intensity in Hyperammonemia

No phase Interventional Brazil

Acute Liver Failure · Acute on Chronic Liver Failure (ACLF) · Acute Kidney Injury