GI & liver — clinical trials

Breast Cancer Survivors · Colorectal (Colon or Rectal) Cancer Survivors · MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis)

Recruiting NCT07046585

Evaluation of the Natera Colorectal Cancer Screening Test in an Average Risk Population (FIND-CRC)

— Observational United States

Colo-rectal Cancer

Recruiting NCT06909188

The Study of Association of Helicobacter Infections in Biliary Tract Cancers

— Observational India

Biliary Tract Cancer

Recruiting NCT05008809

Post-resection/Ablation Chemotherapy in Patients With Metastatic Colorectal Cancer (FIRE-9 - PORT / AIO-KRK-0418)

Phase III Interventional Germany

Colorectal Cancer

Recruiting NCT07217379

The DART DELIVER-02 Study

Phase I Interventional United States, Kenya

HIV (Human Immunodeficiency Virus)

Not yet recruiting NCT07277842

PD-1 + FOLFOXIRI vs CAPOX as Total Neoadjuvant Therapy for pMMR Low Rectal Cancer

Phase III Interventional China

Locally Advanced Low Rectal Adenocarcinoma · pMMR (Microsatellite Stable Rectal Cancer)

Not yet recruiting NCT07276763

Impact of Discontinuing GLP-1 Receptor Agonists for Two Weeks Prior to Upper Endoscopy on the Risk of Gastric Retention

— Observational China

Gastric Retention

Not yet recruiting NCT07277452

Nimotuzumab Combined With Nab-paclitaxel/Gemcitabine in the Perioperative Treatment of High-risk Resectable/Borderline Resectable Pancreatic Cancer

Phase II Interventional China

Pancreatic Cancer, Adult

Enrolling by invitation NCT07015723

Steatosis Assessment Pre-LDLT

— Observational Netherlands

Living Donor Liver Transplantation

Not yet recruiting NCT07276854

Novel Humanized Ferritin-based NIR Fluorescent Molecular Probe for Identifying Tumor Margins in Gastric Tissue

— Observational China

Gastric Cancer · Molecular Imaging

Recruiting NCT04742621

Liver Transplantation for Unresectable Liver Limited Colorectal Metastases

— Observational United States

Unresectable Liver-limited Colorectal Metastases

Not yet recruiting NCT07274657

Superb Microvascular Imaging (SMI) and Two-Dimensional Endoscopic Ultrasound Guided Shear Wave Elastography (2D-SWE-EUS) in Differential Diagnosis of Pancreatic Adenocarcinoma (PA) From Other Pancreatic Solid Lesions (PSLs) and Pancreatic neuroendocrinE Tumors (pNETs) Malignancy

No phase Interventional France

Pancreas Adenocarcinoma (MSI-H) · Pancreatic Neuroendocrine Tumors (pNET)

Recruiting NCT06245356

Safety of Trifluridine/Tipiracil in Patients With Dihydropyrimidine Dehydrogenase Deficiency Diagnosed With Metastatic Colorectal or Gastroesophageal Cancer

Phase II Interventional France

Metastatic Colorectal Cancer · Metastatic Gastroesophageal Adenocarcinoma · DPD Deficiency

Not yet recruiting NCT06656936

The PharmFIT Study

No phase Interventional United States

Colorectal Cancer

Recruiting NCT07275554

Analysis of Methylomic Features and Prognostic Risk Prediction in Patients With Hepatitis B-related Acute-on-chronic Liver Failure

— Observational China

HBV Related Acute-on-chronic Liver Failure · HBV-related Liver Cirrhosis · HBV (Hepatitis B Virus)

Recruiting NCT07242222

Erdosteine in the Treatment of Nonalcoholic Fatty Liver Disease

Phase I / Phase II Interventional Egypt

Fatty Liver

Recruiting NCT06380101

Evaluating a Nonessential Amino Acid Restriction (NEAAR) Medical Food With Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer (LARC)

No phase Interventional United States

Rectal Cancer

Not yet recruiting NCT07275008

Efficacy and Prognosis of Auxiliary Liver Transplantation

— Observational —

Liver Transplantation · Auxiliary Liver Transplantation

Recruiting NCT05639413

A Clinical-biological Prospective Cohort of Patients With BRAFV600E-mutated Metastatic Colorectal Cancer

No phase Interventional France

Metastatic Colorectal Cancer · BRAF V600E Mutation Positive

Recruiting NCT06546969

Chemoimmunotherapy Combined With Hyperthermia and Spatially-Fractionated Radiotherapy in Advanced Biliary Tract Cancer

Phase I Interventional United States

Biliary Tract Cancer · Cholangiocarcinoma

Recruiting NCT07275476

Pregnancy and Fibrin Clot Properties

— Observational Poland

Fibrin Blood Clot · Pregnancy · Pregnancy Complicated by Cardiovascular Disorders as Postpartum Condition, Delivered During Previous Episode

Not yet recruiting NCT07273890

Real-time Feedback of Red-out Within Colonoscopy Intubation

No phase Interventional —

Artificial Intelligence · Colonoscopy · Real-time Feedback

Recruiting NCT06532734

Barrett's Esophagitis in Anorexia Nervosa Binge/Purge Subtype

— Observational United States

Barrett Esophagus · Anorexia Nervosa, Binge Eating/Purging Type · Rumination

Recruiting NCT05993923

Impact of a Multidisciplinary Approach in the Perioperative Geriatrics Unit on Functional Status of Patients Aged 70 and Over Operated on for Colorectal Cancer

No phase Interventional France

Colorectal Cancer · Surgery

Recruiting NCT04578769

Assessment of Different Modified POEM for Achalasia

No phase Interventional China

Esophageal Achalasia

Not yet recruiting NCT07273981

Zanidatamab Combined With Chemotherapy as Neoadjuvant Therapy for HER2-high Expression G/GEJC

Phase II Interventional —

Gastric/Gastroesophageal Junction Adenocarcinoma

Recruiting NCT07272928

Comparison of the Resection Site Order in Simultaneous Approach of Colorectal Liver Metastasis

— Observational Italy

Colorectal Liver Metastasis

Not yet recruiting NCT07272083

New Diagnostic Criteria in the Evaluation Response to Ablation Treatment of Hepatocellular Carcinoma Nodules

— Observational Italy

Hepatocellular Carcinoma

Recruiting NCT04421924

Periinterventional Coagulation Management of Patients Undergoing a TIPS

No phase Interventional Austria

Liver Cirrhosis

Not yet recruiting NCT07271875

Neuromuscular Blocking Agents on Gastrointestinal Function Following Colorectal Surgery

Phase III Interventional —

Postoperative Gastrointestinal Dysfunction (POGD) · Postoperative Ileus · Colorectal Surgery

Recruiting NCT07271576

Research on the Protective Effects of Phycocyanin Against Liver Fibrosis and Cirrhosis

No phase Interventional China

Liver Fibrosis · Liver Cirrhosis

Recruiting NCT06230471

Pembrolizumab With or Without Lenvatinib or Chemotherapy in First-Line Treatment of Advanced Biliary Tract Cancer

Phase II Interventional China

Biliary Tract Neoplasms Immunotherapy

Recruiting NCT07272382

Omega-3 Fatty Acids With PD-1 Inhibitors in Advanced Esophageal Cancer

No phase Interventional China

Esophageal Neoplasms

Enrolling by invitation NCT07273331

Nursing Needs of Patients With Cirrhosis

— Observational Iceland

Cirrhoses, Liver

Recruiting NCT07238283

Irinotecan Hydrochloride Liposome Injection (II)in Combination With Oxaliplatin, 5-FU/LV Versus AG for First-line Treatment of Metastatic Pancreatic Cancer

Phase III Interventional China

First-line Treatment of Metastatic Pancreatic Cancer

Recruiting NCT07221058

Adaptive Radiation Boost for Rectal Cancer

Phase I Interventional United States

Rectum Cancer, Adenocarcinoma

Not yet recruiting NCT07272291

A Phase II Study of Toripalimab Plus Chemotherapy and Low-Dose Radiotherapy for Neoadjuvant Therapy-Refractory Esophageal Squamous Cell Carcinoma

Phase II Interventional —

Esophageal Squamous Cell Carcinoma (ESCC)

Recruiting NCT07272187

Endoscopic Ultrasound-guided Radiofrequency Ablation for Upper Gastrointestinal Tract Lesions

— Observational Denmark

Insulinoma; Pancreas · MEN1 · NETs

Not yet recruiting NCT07152496

Host-Microbe Interactions in Biliary Dilatation

— Observational China

Choledochal Cyst

Recruiting NCT05252754

Rectal Indomethacin and Oral Tacrolimus Versus Combination to Prevent Post-ERCP Pancreatitis

Phase III Interventional United States, India +1

Post-ERCP Acute Pancreatitis

Not yet recruiting NCT07271355

Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial

Phase III Interventional United States

Metastatic Appendix Carcinoma · Metastatic Colorectal Carcinoma · Metastatic Malignant Neoplasm in the Peritoneum

Recruiting NCT07273708

Identification of an Immune Single Cell Transcriptomic Profile of Responder and Non-responder Hepatocellular Carcinoma Patients Treated With Immune-checkpoint Inhibitors

— Observational Italy

Advanced HCC Treated by Systemic Immunotherapy

Recruiting NCT07272772

Colon Cancer Diagnosis With FAPI-PET Imaging

Phase II / Phase III Interventional Finland

Colon Cancer

Recruiting NCT07272200

Understanding Gene ENvironment Interaction in ALcohol-related Hepatocellular Carcinoma

No phase Interventional Italy

HCC · Genetic Predisposition

Recruiting NCT07269626

PULSAR in Systemic Therapy for Pancreatic Cancer

Phase II Interventional South Korea

Locally Advanced Pancreatic Ductal Adenocarcinoma · Borderline Resectable Pancreatic Ductal Adenocarcinoma · Oligometastatic Pancreatic Ductal Adenocarcinoma

Recruiting NCT06584227

Adebrelimab and Chidamide for Pancreatic Cancer

Phase II Interventional China

Pancreatic Cancer, Adult

Not yet recruiting NCT07269158

A Phase IIb Randomized Clinical Trial of Immune Checkpoint Inhibitor-based Maintenance Therapy in Patients With Advanced Biliary Tract Cancer

Phase I / Phase II Interventional South Korea

Biliary Tract Neoplasms · Advanced Cancer · Immunotherapy

Recruiting NCT04430452

Durvalumab With/Without Tremelimumab After Palliative Hypofractionated Radiotherapy for Hepatocellular Carcinoma

Phase II Interventional United States

Advanced Hepatocellular Carcinoma · Stage III Hepatocellular Carcinoma AJCC v8 · Stage IIIA Hepatocellular Carcinoma AJCC v8

Recruiting NCT07270601

Development of a Quantifiable Ultrasound Biomarker for Hepatic Steatosis

No phase Interventional United States

MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease · NAFLD - Non-Alcoholic Fatty Liver Disease

Recruiting NCT07157631

Efficacy and Safety of Tranexamic Acid in Adult Liver Transplantation---ESTA Trial

No phase Interventional China

Liver Transplantation · Tranexamic Acid · End-stage Liver Disease (ESLD)

Not yet recruiting NCT07268677

A Single-arm Clinical Study Evaluating Pirfenidone and Sintilimab in Combination With Standard Neoadjuvant Chemotherapy for Colorectal Cancer Patients With Peritoneal Metastasis.

Phase II Interventional —

Colorectal Cancer

Recruiting NCT07083063

Precise Endoscopic Application of Nitroglycerin in Preventing Post-ERCP Pancreatitis

Phase IV Interventional Taiwan

Pancreatitis

Recruiting NCT06733038

FOLFOXIRI Plus Bevacizumab With or Without Atezolizumab as 1st Line Treatment of pMMR and IS IC-High Metastatic Colorectal Cancer Patients.

Phase III Interventional Italy

Colorectal Cancer

Not yet recruiting NCT07269912

Application of Multimodal MRI in Histological Grading and Prognostic Assessment of Rectal Cancer

— Observational —

Rectal Neoplasms · Prognosis

Recruiting NCT07269249

Real-world Efficacy and Safety of Neoadjuvant Dostarlimab in Patients With dMMR/MSI-H Locally Advanced Rectal Cancer

— Observational Italy

Locally Advanced Rectal Cancer (LARC)

Recruiting NCT07061704

Oncolytic Virus in Esophageal Squamous Cell Carcinoma

Phase I / Phase II Interventional China

Esophageal Cancer

Recruiting NCT03097185

Analysis of Graft Function Following Autologous Islet Transplantation

— Observational United States

Chronic Pancreatitis

Not yet recruiting NCT07270809

To Study the Clinical Course and Outcomes of Non-electively Hospitalised Patients of Chronic Liver Disease (CLD) With Hepatic or Extra-hepatic Predominant Organ Failure(s) at 6 Months.

— Observational India

Chronic Liver Disease

Recruiting NCT07172035

The Impact of Transjugular Intrahepatic Portosystemic Shunt on Recompensation in Patients With Decompensated Liver Cirrhosis

— Observational China

Cirrhosis · Decompensation · Transjugular Intrahepatic Portosystemic Shunt (TIPS)

Not yet recruiting NCT07267208

A Prospective Study to Evaluate the Efficacy and Safety of Entecavir ODT Conversion in Stable Liver Transplant Patients

Phase II Interventional —

Hepatitis B Virus · Liver Transplant

Recruiting NCT07266480

Clinical Study of Adbelimumab in the Adjuvant Treatment of Esophageal Squamous Cell Carcinoma.

Phase II Interventional China

Squamous Oesophageal Cancer

Recruiting NCT07267078

Tuvonralimab and Iparomlimab Based Regimens for the Neoadjuvant Treatment of Biliary Tract Cancer

Phase II Interventional China

Biliary Tract Cancer

Not yet recruiting NCT07265843

Fibrinogen in Liver Transplant

Phase IV Interventional United States

Liver Transplant Surgery

Recruiting NCT06610760

Efficacy and Safety of Ursodeoxycholic Acid in Reversing Gastric Intestinal Metaplasia

Phase IV Interventional China

Gastric Intestinal Metaplasia

Enrolling by invitation NCT03123835

Outcome Analysis of POEM and Endoluminal Therapies

No phase Interventional United States

Achalasia · Gastric Fistula · Weight Gain After Primary Weight Loss Surgery

Recruiting NCT06032104

Feasibility and Colorectal Benefits of Pulses Supplementation

No phase Interventional United States

Colorectal Polyp · Obesity

Not yet recruiting NCT07208864

Efficacy of an AI System in Training Endoscopists to Assess Gastric Intestinal Metaplasia Via the EGGIM Score

No phase Interventional China

Gastric Intestinal Metaplasia

Recruiting NCT07266493

Efficacy and Safety of Neoadjuvant Envafolimab Combined With Albumin-bound Paclitaxel and Carboplatin for Resectable Locally Advanced Esophageal Squamous Cell Carcinoma

Phase II Interventional China

Esophageal Squamous Cell Carcinoma · Neoadjuvant Therapy

Recruiting NCT06731894

Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors

Phase II Interventional United States

Breast Carcinoma · Chemotherapy-Induced Peripheral Neuropathy · Colon Carcinoma

Recruiting NCT04570943

Sequential Treatment With GEMBRAX and Then FOLFIRINOX Followed by Stereotactic MRI-guided Radiotherapy in Patients With Locally Advanced Pancreatic Cancer

Phase II Interventional France

Locally Advanced Pancreatic Adenocarcinoma

Not yet recruiting NCT07265817

Fecal Microbiota Transplantation for Decolonization of Multidrug-resistant Microorganisms

No phase Interventional —

Carbapenem-Resistant Enterobacteriaceae Colonization

Recruiting NCT07264556

Effect of OFA, OSA Versus Opioid-based Anesthesia on NETs and Cancer Cell Malignancy After Colorectal Cancer Surgery

No phase Interventional China

Colorectal Cancer · Opioid-free Anesthesia · NETs

Recruiting NCT07263217

Mechanistic Study on the Protective and Regenerative Effects of Spirulina in Hepatectomy-Related Liver Injury

No phase Interventional China

Cholangiocarcinoma

Recruiting NCT07263178

A Study of Second- and Later-line Palliative Chemotherapy in Patients With Metastatic Colorectal Cancer.

— Observational South Korea

Metastatic Colorectal Cancer

Recruiting NCT06402864

Evaluation Contact X-ray Brachytherapy for Rectal Preservation in Intermediate Substage Rectal Adenocarcinoma

Phase III Interventional France

Adult With Intermediate Low or Mid Rectal Adenocarcinoma

Recruiting NCT07193446

Optimising the Delivery of Diabetes Distress Informed Care for Its Prevention, Detection, and Management in Adults With Type 1 Diabetes: a Feasibility Study (D-stress Study)

No phase Interventional United Kingdom

Diabetes Type 1

Recruiting NCT06376474

To Evaluate the Pharmacokinetics of Hemay005 Tablets in Subjects With Liver Damage

Phase I Interventional China

Psoriasis

Not yet recruiting NCT07263360

Iparomlimab and Tuvonralimab Injection Combined With GemOX and Lenvatinib as Conversion Therapy for Initially Potentially Resectable Intrahepatic Cholangiocarcinoma and Gallbladder Cancer

Phase II Interventional China

BTC

Recruiting NCT06236633

Safety & Efficacy of Ischemic Preconditioning by Embolization of the Inferior Mesenteric Artery in Surgery for Tumors of Lower and Middle Rectum

No phase Interventional France

Cancer, Rectal

Recruiting NCT06856863

Correlation Between Personnality Traits and Ability to Learn Oroesophageal Voice

No phase Interventional France

Laryngectomy · Total Pharyngo-laryngectomy