GI & liver

8,202 trials in this section

Recruiting NCT07481357

A First-In-Human Phase I/IIa Study to Evaluate DA 3501 in Patients With Advanced Gastric or Gastro-esophageal Junction Adenocarcinoma and Pancreatic Ductal Adenocarcinoma

Phase I Interventional South Korea

Gastric (Stomach) Cancer · GastroEsophageal Cancer · Pancreatic Ductal Adenocarcinoma (mPDAC)

Recruiting NCT07600268

Efficacy of Stereotactic Body Radiotherapy (SBRT) Combined With Maintenance Therapy Compared to Maintenance Therapy Alone in Advanced Pancreatic Cancer

Phase II Interventional China

Pancreatic Cancer Non-resectable

Recruiting NCT06860815

Cemiplimab and Transarterial Radioembolization With Y-90 SIR-S Spheres for the Treatment of Liver Directed Metastatic Breast Cancer

Phase II Interventional United States

Anatomic Stage IV Breast Cancer AJCC v8 · Metastatic Breast Carcinoma · Metastatic Carcinoma in the Liver

Recruiting NCT06959550

Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer

Phase II Interventional United States

Metastatic Colorectal Cancer

Recruiting NCT07599241

Additive Efficacy of Physical Activity Program in Hypthyroidism Elder Females With Glaucoma and Fatty Liver Issues

No phase Interventional Egypt

Subclinical hypothyroïdism · Non-Alcoholic Fatty Liver Disease · Primary Open Angle Glaucoma

Recruiting NCT06673017

PTM-101 in Pancreatic Ductal Adenocarcinoma (PDAC)

Phase I Interventional United States

Pancreatic Ductal Adenocarcinoma · Borderline Resectable Pancreatic Adenocarcinoma · Locally Advanced Pancreatic Adenocarcinoma

Not yet recruiting NCT07599527

Megarectum in Adults

— Observational France

Idiopathic Megarectum

Enrolling by invitation NCT07247877

Research on Using Small-for-size Grafts for Auxiliary Liver Transplantation in the Treatment of Portal Hypertension

— Observational —

Liver Transplantation

Recruiting NCT07600411

Binge Eating, Depression and Anxiety Outcomes After Sleeve Gastrectomy Versus Gastric Bypass: A Cohort Study

No phase Interventional Egypt

Obesity

Not yet recruiting NCT07595523

Iparomlimab Tolvorlimab as Neoadjuvant Immunotherapy for Locally Advanced Gastric Adenocarcinoma With Microsatellite Instability/Mismatch Repair Deficiency

Phase II Interventional —

Gastric Cancer

Recruiting NCT04662905

Novel Treatment Delivery of ECAP-controlled Closed-loop SCS for Chronic Pain

No phase Interventional Australia

Chronic Pain

Recruiting NCT04054310

Non-Invasive Quantification of Liver Health in NASH (N-QUAN)

No phase Interventional United States

NASH - Nonalcoholic Steatohepatitis

Recruiting NCT07561840

Exercise Training After Upper Gastrointestinal Cancer Surgery

No phase Interventional Japan

Esophageal Cancer · Gastric Cancer (Diagnosis) · Upper Gastrointestinal Cancer

Recruiting NCT04846309

Hypoxia Imaging for Esophageal Cancer to Guide Personalized Radiation Therapy

Phase I Interventional United States

Esophageal Cancer

Not yet recruiting NCT07595276

Comparing Efficacy and Safety of Enlituo® Versus Erbitux® Plus FOLFOX in Locally Advanced/Metastatic Colorectal Cancer With RAS/BRAF Wild-type and MSS/pMMR Status.

Phase III Interventional China

Colorectal Cancer

Recruiting NCT05468359

Safety and Efficacy of Cyclophosphamide, Sorafenib, Bevacizumab, and Atezolizumab in Pediatric Solid Tumor Patients

Phase I / Phase II Interventional United States

Refractory Solid Tumor · Hepatocellular Carcinoma · Malignant Solid Tumor

Recruiting NCT07597772

Preliminary Trial of SNA014 for Pancreatic Cancer

Early Phase I Interventional China

Pancreatic Cancer

Recruiting NCT07594925

Short-Course Radiotherapy Followed by Immunotherapy Combined With Chemotherapy for Microsatellite Stable Locally Advanced Rectal Cancer: A Prospective, Randomized, Controlled Phase II Clinical Trial

Phase II Interventional China

Rectal Cancer

Recruiting NCT07595770

Adebrelimab Combined With Neoadjuvant Chemoradiotherapy for Esophageal Squamous Cell Carcinoma

Phase II Interventional China

Esophageal Squamous Cell Carcinoma (ESCC)

Recruiting NCT07594964

To Evaluate the Safety, Tolerability, and Preliminary Efficacy of XH001 Injection as Adjuvant Therapy in Patients With High-risk Recurrent Solid Tumors

Phase I Interventional China

Biliary Cancer (Cholangiocarcinoma, Gall Bladder Cancer) · Pancreatic Ductal Adenocarcinoma (PDAC) · Hepatocellular Carcinoma (HCC)

Recruiting NCT05884723

Preoperative Ketogenic Diet for Reduction of Hepatic Steatosis

No phase Interventional Canada

Liver Steatoses · Liver Metastasis Colon Cancer · NAFLD

Not yet recruiting NCT07595107

Concordance Between Large Language Model and Multidisciplinary Team Recommendations in Rectal Cancer

— Observational China

Rectal Cancer

Not yet recruiting NCT07594626

BMS-986504 in Combination With Pemetrexed for the Treatment of Metastatic Solid Tumors With MTAP Deletion

Phase I / Phase II Interventional United States

Metastatic Biliary Tract Carcinoma · Metastatic Colon Carcinoma · Metastatic Esophageal Carcinoma

Recruiting NCT06529718

Testing Ivonescimab Versus FOLFOX in Advanced Biliary Tract Cancer Patients

Phase II Interventional France, United Kingdom

Biliary Tract Cancer

Recruiting NCT06929845

Organoid Models of Hepatocellular Carcinoma

No phase Interventional Italy

Hepatocellular Carcinoma · Organoids · Gut Microbiota

Not yet recruiting NCT07595627

Hypothermic Machine Perfusion for Liver Graft Preservation

No phase Interventional Brazil

Liver Transplant · Liver Failure

Recruiting NCT04901702

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

Phase I / Phase II Interventional United States, Canada

Recurrent Solid Tumor · Recurrent Ewing Sarcoma · Recurrent Hepatoblastoma

Recruiting NCT07561632

Predictive Value of Early Peritraumatic Distress Screening for Childbirth-PTSD Following Unplanned Cesarean Delivery

— Observational Canada

Post Traumatic Stress Disorder · Post Partum Depression · Acute Stress Symptoms

Recruiting NCT05038358

Tumor Immune Microenvironment Involvement in Colorectal Cancer Chemoresistance Mechanisms

— Observational France

Primary Tumor · Colon Tumor

Recruiting NCT07595237

A IIT Study of 177Lu-DOTA-SNA040

Early Phase I Interventional China

Advanced Solid Tumors (Such as Gastric Cancer) · Advanced Solid Tumors (Such as Adenocarcinoma at the Gastroesophageal Junction) · Advanced Solid Tumors (Such as Pancreatic Cancer)

Recruiting NCT07595003

Efficacy, Safety, and Tolerability of 4-MUST, 128 mg Tablets in Chronic Cholecystitis and Biliary Dyskinesia

Phase III Interventional Russia

Chronic Cholecystitis · Biliary Dyskinesia

Recruiting NCT05615818

Personalized Medicine for Advanced Biliary Cancer Patients

Phase III Interventional Belgium, France +1

Biliary Tract Neoplasms

Recruiting NCT07488611

PROGAIN Trial in Gastric Cancer Surgery

Phase III Interventional South Korea

Stomach (Gastric) Cancer

Recruiting NCT07595172

NALIRIFOX+Adebrelimab+PULSAR for Advanced Pancreatic Cancer

Phase I / Phase II Interventional China

Pancreatic Ductal Adenocarcinoma (PDAC) · Locally Advanced and Metastatic Pancreatic Cancer

Recruiting NCT05169177

Radio-opaque Contrast Agents for Liver Cancer Targeting With KIM During Radiation Therapy

— Observational Australia

Liver Neoplasm

Recruiting NCT07317076

GT Metabolic Magnet System in Adults With Gastrointestinal Disorders

No phase Interventional Canada

Gastric Outlet Obstruction · Small Bowel Obstruction · Superior Mesenteric Artery Syndrome

Recruiting NCT04106518

Study of Genetic Determinants in Alcoholic Hepatitis and Establishment of a Multicenter Prospective Cohort of Patients With Alcoholic Liver Disease

— Observational France

Alcoholic Liver Disease · Severe Alcoholic Hepatitis · Alcoholic Cirrhosis

Recruiting NCT07431723

Creation of Compression Anastomosis Using the GT Metabolic Magnet System

No phase Interventional Chile, Italy

Anastomosis, Functional · Colorectal

Recruiting NCT05884255

An Open-label Phase 3 Study of Lutetium (177Lu) Oxodotreotide Injection in Subjects With Advanced Gastrointestinal Pancreatic Neuroendocrine Tumors.

Phase III Interventional China

Advanced Gastroenteropancreatic Neuroendocrine Tumor

Recruiting NCT07144683

Anastomotic Leakage After Colorectal Surgery.

— Observational Egypt

Anastomotic Leak · Colorectal Cancer · Diverticulitis

Not yet recruiting NCT07359456

Testing Ivonescimab in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancers Without Liver Metastases

Phase II Interventional France

Metastatic Colorectal Cancer

Recruiting NCT05184790

LEARN: Learning Environment for Artificial Intelligence in Radiotherapy New Technology

— Observational Australia

Arrhythmias, Cardiac · Breast Cancer · Prostatic Cancer

Recruiting NCT06904378

ONT01 and Gemcitabine/Nab-paclitaxel as Second Line Therapy for Metastatic Pancreatic Ductal Adenocarcinoma

Phase I / Phase II Interventional United States

Metastatic Pancreatic Ductal Adenocarcinoma

Recruiting NCT06414902

18F-AraG PET/CT as a Non-Invasive Imaging Biomarker for Chemoradiation Treatment Response in Esophageal Cancer

Phase I Interventional United States

Esophageal Cancer

Recruiting NCT05404230

Prevention of Oxaliplatin-induced Nerve Damage in the Body's Extremities

No phase Interventional Denmark

Peripheral Neuropathy · Colorectal Cancer

Not yet recruiting NCT07524699

A Study About Remote and Local Liver Surgery

No phase Interventional China

Liver Diseases

Not yet recruiting NCT07490405

Long-term Efficacy and Safety of LSD Versus TIPS for Cirrhotic Portal Hypertension Bleeding and Hypersplenism

— Observational China

Liver Cirrhosis

Recruiting NCT06769113

A Phase II Clinical Study to Evaluate HLX43 in Patients With Recurrent/Metastatic ESCC Failed or Intolerance to Standard Therapy

Phase II Interventional China

Esophageal Cancer

Not yet recruiting NCT07581574

Neoadjuvant SHR-A1811 and SHR-A1701 for Potentially Immunotherapy-Sensitive GC or GEJ Adenocarcinoma

Phase I Interventional China

Gastric or Gastroesophageal Junction Adenocarcinoma

Recruiting NCT07420426

Instant Message-delivered Personalised Acceptance and Commitment Therapy (IMPACT) for Neuropsychiatric Symptoms in Persons With Mild Cognitive Impairment

No phase Interventional Hong Kong

Mild Cognitive Impairment (MCI)

Recruiting NCT04731272

GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance

Phase II Interventional United States

Cystic Fibrosis · Pancreatic Insufficiency · Abnormal Glucose Tolerance

Not yet recruiting NCT07592819

A Trial Using Transcriptomic Signatures to Personalize Neoadjuvant Chemotherapy (NAC) for Patients With Resectable Borderline Pancreatic Adenocarcinoma (PDAC)

No phase Interventional —

Pancreas Adenocarcinoma (MSI-H) · Pancreatic Cancer Resectable

Recruiting NCT07377656

Strengthening HPV Immunization Through EPI Leveraged Delivery

Phase II Interventional Ghana

HPV Vaccine

Not yet recruiting NCT07591597

A Multicenter, Phase Ib/II Clinical Trial to Evaluate the Efficacy and Safety of Concurrent Combination Therapy of S-531011 Plus Fruquintinib or S-531011 Plus Fruquintinib Plus Pembrolizumab in Patients With MSS/pMMR Colorectal Cancer

Phase I / Phase II Interventional —

Metastatic Colorectal Neoplasms · Microsatellite Stable / Proficient Mismatch Repair Colorectal Cancer

Enrolling by invitation NCT05788029

Comparing Laparoscopic and Open Pancreaticoduodenectomy for Nonpancreatic Periampullary Adenocarcinomas

No phase Interventional China

Periampullary Adenocarcinoma

Recruiting NCT01514045

The Gastric Cancer Foundation: A Gastric Cancer Registry

— Observational United States

Gastric Cancer

Recruiting NCT06824064

Evaluation of RBS2418 in Patients With Advanced, Metastatic, and Progressive Colorectal Cancer

Phase II Interventional United States, Puerto Rico +1

Metastatic Colorectal Cancer · Advanced Colorectal Cancer

Recruiting NCT07495111

Prophylactic PS Placement to Prevent Pancreatitis After Endoscopic Transpapillary GPC for Cholelithiasis With Concomitant Choledocholithiasis

No phase Interventional China

Cholelithiasis Associated With Common Bile Duct Stones

Recruiting NCT06682481

Beta-Cell - Liver Interactions in Situations of Modified Beta-Cell Function

— Observational Switzerland

Obesity, Childhood · Type 2 Diabetes Mellitus in Obese

Not yet recruiting NCT07593638

Plasma Exchange Half-dose and Extracorporeal Detoxification for ACLF

No phase Interventional Portugal

Acute on Chronic Liver Failure (ACLF)

Recruiting NCT05947838

A Prospective Feasibility Study Using ctDNA to Tailor Neoadjuvant Chemotherapy for Patients With Colorectal or Appendiceal Adenocarcinoma

No phase Interventional United States

Appendiceal Adenocarcinoma · Colorectal

Recruiting NCT07461610

Stool Analysis After Sleeve Gastrectomy vs Gastric Bypass

— Observational Egypt

Morbid Obesity

Recruiting NCT06288711

Novel Telemedicine-Delivered Prolonged Exposure Therapy for Treating PTSD in Individuals With OUD

No phase Interventional United States

Opioid Use Disorder · Posttraumatic Stress Disorder

Not yet recruiting NCT07585786

Effect of LSD on Renal Function in Cirrhosis Patients With Portal Hypertension Bleeding (2-Year Follow-Up)

— Observational —

Cirrhosis, Liver · Splenectomy; Status · Renal Function Abnormal

Recruiting NCT05727020

Volatile Organic Compound Assessment in Pancreatic Ductal Adenocarcinoma

— Observational United Kingdom

PDAC - Pancreatic Ductal Adenocarcinoma · Pancreatic Cancer

Recruiting NCT07040228

A Phase Ib/II Clinical Study of Regorafenib Combined With Toripalimab and Albumin-bound Paclitaxel for the Third-line Treatment of Advanced Pancreatic Cancer

Phase I / Phase II Interventional China

Pancreatic Cancer Metastatic

Enrolling by invitation NCT07592013

Effect of Ancestry Supplementation in Subjects With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

No phase Interventional Mexico

MASLD

Enrolling by invitation NCT06463223

HIBOC = Hepatic Imaging Biomarkers in Obese Children

— Observational Sweden

Elastography · Shear Wave Elastography · Shear Wave Dispersion

Recruiting NCT07026422

Iparomlimab/Tuvonralimab Integrating With Total Neoadjuvant Therapy for pMMR/MSS Locally Advanced Rectal Cancer (IT-TNT)

Phase II Interventional China

Rectal Malignant Neoplasms

Not yet recruiting NCT07581626

Short-Course Online Adaptive Radiotherapy Combined With Chemotherapy, Targeted Therapy and Immunotherapy as Total Neoadjuvant Therapy (TNT) for Locally Advanced Rectal Cancer

Phase II Interventional China

Locally Advanced Rectal Cancer (LARC)

Not yet recruiting NCT07594548

Futibatinib With Paclitaxel and Ramucirumab for the Treatment of Locally Advanced or Unresectable Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

Phase I Interventional United States

Clinical Stage II Esophageal Adenocarcinoma AJCC v8 · Clinical Stage III Esophageal Adenocarcinoma AJCC v8 · Clinical Stage III Gastric Cancer AJCC v8

Recruiting NCT04421820

BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours

Phase I / Phase II Interventional United States, Canada +5

Colorectal Cancer · Pancreatic Cancer · Gastric Cancers

Not yet recruiting NCT07590336

68Ga-NYM207 PET/CT Imaging in Hepatocellular Carcinoma

Phase I / Phase II Interventional China

Hepatocellular Carcinoma (HCC)

Recruiting NCT06649292

SHR-A1904 Compared With Investigator's Choice of Therapy in Claudin18.2 Positive Patitens With Second-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

Phase III Interventional China

Second-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

Recruiting NCT07591571

To Evaluate the Preliminary Efficacy of Our Digitally Enhanced CHW-led Intervention in Newly Diagnosed PDAC

No phase Interventional United States

Pancreatic Cancer, Adult

Not yet recruiting NCT07551596

Testing the Combination of Anti-Cancer Drugs, Botensilimab (AGEN1181) and Balstilimab (AGEN2034), After Standard Treatment for Colorectal Cancer, Combat Trial

Phase II Interventional —

Colorectal Adenocarcinoma · Stage II Colorectal Cancer AJCC v8 · Stage III Colorectal Cancer AJCC v8

Not yet recruiting NCT07111130

Restoring Bile Acid Homeostasis Via Lifestyle Adjustments to Prevent the Development of Liver Cancer

No phase Interventional Singapore

Liver Diseases

Recruiting NCT05698992

Rehabilitation and Recovery for Persons With Esophageal or Gastric Cancer

— Observational Sweden

Esophageal Cancer · Esophageal Neoplasms · Gastric Cancer

Not yet recruiting NCT07591480

Barriers And Facilitators To Clinical Trial Enrollment: A Qualitative Study Of Pancreatic Cancer Patients

— Observational United States

Pancreatic Cancer

Not yet recruiting NCT07574502

Transcutaneous Electrical Acustimulation on Postoperative Bowel Function Recovery in Elderly Patients

No phase Interventional China

Colorectal Cancer (CRC)

Not yet recruiting NCT07590284

Sonazoid CEUS for Early HCC Surveillance

No phase Interventional China

Liver Cirrhosis · Liver Fibrosis

Not yet recruiting NCT07138846

A Study Comparing MRG004A Plus Best Supportive Care Versus Placebo and Best Supportive Care in the Treatment of Patients With Advanced Pancreatic Cancer

Phase III Interventional China

Advanced Pancreatic Cancer

Recruiting NCT05627219

Extending Prostate Genetic Awareness, Navigation, and Delivery: The EXPAND Network

— Observational United States

Metastatic Prostate Carcinoma · Stage IIIB Prostate Cancer AJCC v8 · Stage IIIC Prostate Cancer AJCC v8

Recruiting NCT06302621

Pemigatinib + Afatinib in Advanced Refractory Solid Tumors

Phase I Interventional United States

Advanced Solid Tumor · Unresectable Solid Tumor · Metastatic Solid Tumor

Recruiting NCT07438106

A Phase II Study of HRS-4642 Combined With AG (Nab-paclitaxel and Gemcitabine) as Conversion Therapy for Locally Advanced Pancreatic Cancer

Phase II Interventional China

Locally Advanced Pancreatic Cancer With KRAS G12D Mutation

Recruiting NCT06300463

Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases

Phase II Interventional United States

Colorectal Cancer Metastatic · Liver Metastases · Colorectal Cancer

Recruiting NCT05783375

Accelerating Delivery of rheUmatic Heart Disease Preventive iNterventions in Northern Uganda

No phase Interventional Uganda

Rheumatic Heart Disease

Recruiting NCT07591246

Efficay of Physical Activity Program in PCOS Females With Fatty Pancrease and Thyroid Hypofunction

No phase Interventional Egypt

Polycystic Ovary Syndrome · Non-Alcoholic Fatty Pancreatic Disease · Subclinical hypothyroïdism

Recruiting NCT07588854

Correlation Of EUS-SWQ And Liver Fibrosis Pathology In Chronic Liver Disease

— Observational China

Chronic Liver Disease (CLD) · Liver Fibrosis

Not yet recruiting NCT07572708

Transcutaneous Electrical Acustimulation (TEA) for the Treatment of Non-Erosive Gastroesophageal Reflux Disease (NERD)

No phase Interventional China

Non-erosive Reflux Disease (NERD)

Not yet recruiting NCT07588568

A Trial of Upadacitinib for Non-responsive Eosinophilic Esophagitis

Phase II Interventional United States

EoE · Eosinophilic Esophagitis · Eosinophilic Esophagitis (EoE)

Recruiting NCT07280390

Microplastics, Cirrhosis and Portal Hypertension

— Observational India

Cirrhosis · Microplastics · Portal Hypertension Related to Cirrhosis

Recruiting NCT07401199

Multimodal AI for Predicting Response to Neoadjuvant Immunotherapy in Gastric Cancer (PRISM-GC)

— Observational China

Gastric Cancer (GC) · Locally Advanced Gastric Cancer

Recruiting NCT06691893

Evaluating the Efficacy of RELiZORB in Managing Exocrine Pancreatic Insufficiency in Tube-fed Pancreatitis Patients

Phase III Interventional United States

Exocrine Pancreatic Insufficiency (EPI) · Pancreatitis

Not yet recruiting NCT07590856

A Preliminary Efficacy of SNA028 in Patients With Advanced Colorectal Cancer Positive for GPA33

Early Phase I Interventional China

Colorectal Cancer

Recruiting NCT05402696

St. Paul's Advanced Resection Center Cohort for Colorectal Neoplasia (SPARC-C)

— Observational United States, Canada +1

Colon Adenoma · Colon Polyp · Colon Lesion

Not yet recruiting NCT07591493

Adjuvant Trial in Pancreatic Neuroendocrine Tumors

Phase III Interventional France

Pancreatic Neuroendocrine Tumors (pNET) · Pancreatic Neuroendocrine Tumors

Recruiting NCT06580574

Immune Checkpoint Inhibitors for Organ Preservation in Non-metastatic dMMR/MSI-H Gastric or Colon Cancers

Phase II Interventional China

Gastric Cancer · Colon Cancer · MSI-H

Not yet recruiting NCT07589400

Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Characteristics of ACT500 in Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease Complicated With Chronic Hepatitis B

Phase I Interventional China

Metabolic Dysfunction-associated Steatotic Liver Disease · Chronic Hepatitis b

Recruiting NCT05925309

Preventive Effect of Prophylactic Oral Antibiotics Against Cholangitis After Kasai Portoenterostomy

No phase Interventional China

Biliary Atresia · Cholangitis · Anti-Bacterial Agents