Recruiting NCT06144151
A Pilot Study for Pupillary Assessment to Predict CAR-T Related Neurotoxicity
Neurotoxicity
CAR-T & cell therapy
1,352 trials in this section
Recruiting NCT06121843
A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma
Multiple Myeloma
Not yet recruiting NCT07596680
CD19/BCMA-Targeted Universal CAR-T Cell Injection for the Treatment of Autoimmune Diseases
SLE - Systemic Lupus Erythematosus · Systemic Sclerosis · ANCA Associated Vasculitis
Recruiting NCT05464719
A Phase II Study of Loncastuximab Tesirine as Consolidation Strategy in Patients With LBCL in PR After CAR T-cell Therapy
Large B-cell Lymphoma · Lymphoma
Recruiting NCT07479797
Study Evaluating the Efficacy of KITE-753 Versus Axicabtagene Ciloleucel in Participants With Relapsed or Refractory Large B-Cell Lymphoma After First-Line Therapy
Relapsed or Refractory Large B-cell Lymphoma
Recruiting NCT07382817
Phase 1 Study of JV-394 Autologous Anti-CD94 CAR T for r/r CD94+ T/NK Cell Neoplasms
Neoplasms
Not yet recruiting NCT07701889
Bispecific CD19/CD20-Targeted Chimeric Antigen Receptor (CAR) Modified T Cells With 4-1BB and Mutated CD28 Costimulatory Domains in Patients With Relapsed or Refractory CD19+ Hematologic Malignancies
Hematologic Diseases
Recruiting NCT03093909
Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases
Malignant Neoplasm of Bone and Articular Cartilage · Malignant Neoplasms of Female Genital Organs · Malignant Neoplasms of Independent (Primary) Multiple Sites
Recruiting NCT06575712
Coping Skills Training for Symptom Management and Daily Steps (Step Up)
Hematopoietic Stem Cell Transplant · CAR-T Cell Therapy
Not yet recruiting NCT07164469
Phase 2 Trial of CD70.CAR NK Cells for Patients With Primary Refractory or Early Relapsed Diffuse Large B-Cell Lymphoma and Hodgkin Lymphoma
Large B-cell Lymphoma · Hodgkin Lymphoma
Recruiting NCT07341191
Sonrotoclax Plus Zanubrutinib in Patients With Relapsed/Refractory Mantle Cell Lymphoma Planned for Standard of Care CAR-T Cell Therapy
Mantle Cell Lymphoma
Recruiting NCT07689305
Live Parent-Child Video Interaction and Cartoon Watching for Emergence Agitation in Children
Emergence Delirium · Preoperative Anxiety
Recruiting NCT07115745
A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases
Refractory Autoimmune Diseases
Enrolling by invitation NCT03167203
A Safety Surveillance Study in Subjects With Macular Degenerative Disease Treated With Human Embryonic Stem Cell-derived Retinal Pigment Epithelial Cell Therapy
Macular Degenerative Disease
Recruiting NCT06652633
Long-term Follow-up of Participants Treated With Galapagos Chimeric Antigen Receptor (CAR) T-cell Therapies
Hematological Malignancies
Recruiting NCT07416682
CAR BCMA-70 CAR-T Cells for the Treatment of High-risk Plasma Cell Neoplasms
High-risk Plasma Cell Neoplasms
Recruiting NCT04792489
DALY II USA/ MB-CART2019.1 for DLBCL
Refractory Diffuse Large B Cell Lymphoma (DLBCL) · Relapsed Diffuse Large B Cell Lymphoma · High Grade B-cell Lymphoma (HGBCL)
Recruiting NCT07075523
Neuroimaging and Biomarkers of Neurotoxicity After Chimeric Antigen Receptor T-Cell Therapy
CAR T-Cell Therapy
Recruiting NCT07567040
Delaying the Onset of Nearsightedness Until Treatment (DONUT) Clinical Trial
Myopia
Not yet recruiting NCT07395050
Autologous CD6-CAR Treg Cells for Patients With Stage 3 Type 1 Diabetes
Stage 3 Type 1 Diabetes
Recruiting NCT07695012
CAR-T Cell Therapy for ALL
Relapsed Acute Lymphoblastic Leukemia (ALL)
Recruiting NCT05077527
Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma
AIDS-Related Diffuse Large B-cell Lymphoma · AIDS-Related Non-Hodgkin Lymphoma · HIV Infection
Recruiting NCT05098613
Preliminary Safety and Tolerability of CD19x22 CAR T Cells in Adolescent and Adult R/R B-NHL Patients
Non-Hodgkin Lymphoma · B-cell Non-Hodgkin Lymphoma (B-NHL) · Mantle Cell Lymphoma (MCL)
Recruiting NCT07432334
CD19 CAR T-Cell Therapy for Refractory Systemic Lupus Erythematosus
Refractory Systemic Lupus Erythematosus
Recruiting NCT05945849
CD33KO-HSPC Infusion Followed by CART-33 Infusion(s) for Refractory/Relapsed AML
Leukemia, Myeloid, Acute
Recruiting NCT07575555
The Effect of Lipedema on Knee Osteoarthritis
Lipedema · Knee Osteoarthritis · Knee Acute and Chronic Pain
Recruiting NCT06185751
Safety and Efficacy of CS1 CAR-T (WS-CART-CS1) in Subjects With Multiple Myeloma
Multiple Myeloma
Recruiting NCT07509450
Fecal Microbiota Transplantation in Patients Undergoing Chimeric Antigen Receptor T-cell Therapy and Allogeneic Stem Cell Transplant: A Pilot Study
Lymphoma Receiving CAR-T Therapy
Recruiting NCT06915363
BioPoly® Partial Resurfacing Knee Implant IDE
Knee Pain Chronic · Knee Osteoarthritis · Cartilage Damage
Recruiting NCT06798298
A Safety and Efficacy Long-Term Follow-up Study of Adult Participants Treated With Gene Modified T Cells
Long Term Safety Following GM T Cell Therapy
Recruiting NCT07689058
CAR-T in Relapsed/Refractory Multiple Myeloma
Multiple Myeloma Refractory · Multiple Myeloma in Relapse
Recruiting NCT06655896
Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Diffuse Cutaneous Systemic Sclerosis
Scleroderma, Diffuse
Recruiting NCT06096038
Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCC
Head and Neck Cancer · Relapse · Recurrent
Recruiting NCT06854159
Odronextamab for the Treatment of Relapsed and Refractory Diffuse Large B-cell Lymphoma Before and After Chimeric Antigen Receptor T-cell Therapy
Recurrent Diffuse Large B-Cell Lymphoma · Recurrent Transformed Follicular Lymphoma to Diffuse Large B-Cell Lymphoma · Refractory Diffuse Large B-Cell Lymphoma
Recruiting NCT07464951
CART123 Cells With or Without Ruxolitinib in Relapsed/Refractory Acute Myeloid Leukemia
Acute Myeloid Leukemia (AML)
Recruiting NCT06934382
Anti-CD7 CAR-T Cells in Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia or Lymphoma
T-Cell Acute Lymphoblastic Leukemia/Lymphoma
Recruiting NCT07249489
Nanochon Chondrograft First in Human (FIH) Early Feasibility Study (EFS) - Canada
Knee Cartilage Lesions
Recruiting NCT06285279
The BCMA/CD19 Dual Targeted CAR-T Cell in Participants With Autoimmune Kidney Diseases
Lupus Nephritis · ANCA-associated Vasculitis · Membranous Nephropathy - PLA2R Induced
Recruiting NCT05201781
A Long-term Study for Participants Previously Treated With Ciltacabtagene Autoleucel
Multiple Myeloma
Not yet recruiting NCT07542184
Nanochon Chondrograft First in Human (FIH) Early Feasibility Study (EFS) - Panama
Knee Cartilage Lesions
Recruiting NCT07149857
A Study to Evaluate Efficacy and Safety of Ciltacabtagene Autoleucel
Multiple Myeloma
Not yet recruiting NCT07240649
Emerging Indications for Hyperbaric Oxygen Treatment
Post-COVID-19 Condition · Ulcerative Colitis · Crohn Disease
Recruiting NCT06408194
Autologous CD22 CAR T Cells Following Commercial CD19 CAR T Cells in B Cell Malignancies
Leukemia · Acute Lymphoblastic Leukemia
Recruiting NCT07680257
An Early Clinical Study to Evaluate the Safety and Efficacy of CLDN18.2 CAR T Cell Injection in Subjects With CLDN18.2-Positive Advanced Malignant Solid Tumors
CLDN18.2 Positive Solid Tumors
Recruiting NCT06227026
Pilot Study of Anti-CD19 Chimeric Antigen Receptor T Cells (CAR-T Cells) for the Treatment of Relapsed/Refractory CD19+ Malignancies
Acute Lymphoblastic Leukemia · Diffuse Large B Cell Lymphoma
Recruiting NCT07081646
A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.
Relapsed AL Amyloidosis · Refractory AL Amyloidosis · Light Chain Amyloidosis
Recruiting NCT06490770
Analysis of the Pathophysiological and Functional State of the Knee Joint
Osteoarthritis, Knee · Cartilage Degeneration
Recruiting NCT07681388
CD19 CAR-T Therapy for Refractory Pemphigus Vulgaris
Pemphigus Vulgaris
Recruiting NCT07505199
Safety and Efficacy of FAP iCDC in Ischemic Cardiomyopathy
Ischemic Cardiomyopathy · Cell Therapy
Not yet recruiting NCT06946680
IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Newly Diagnosed and Recurrent Pediatric High-grade Glioma (pHGG) and Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ndDIPG)
High-grade Glioma · Diffuse Intrinsic Pontine Glioma
Not yet recruiting NCT07678307
A Multicenter, Open-label, Non-randomized, Single-arm Phase 1/2 Study of Autologous Nano CD5-CAR T Cells for the Treatment of Relapsed/Refractory T-cell Acute Lymphoblastic Leukemia/Lymphoma
T-Cell Acute Lymphoblastic Leukemia · T-Lymphoblastic Lymphoma · Relapsed/Refractory Hematologic Malignancies
Recruiting NCT06710288
A Phase 2, Open-label, Single-arm Study Of Autologous M-CENK Adoptive Cell Therapy And N-803 (IL-15 Superagonist) In Combination With Gemcitabine In Participants With Recurrent Platinum-Resistant High-Grade Ovarian Cancer
Platinum-resistant Ovarian Cancer
Recruiting NCT05225363
Modified Immune Cells (TAG72-CAR T Cells) for the Treatment of Patients With Platinum Resistant Epithelial Ovarian Cancer
Platinum-Resistant Ovarian Carcinoma
Recruiting NCT06996119
Emapalumab With Post-Transplant Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Graft-versus-Host Disease After Donor Reduced-Intensity Hematopoietic Cell Transplant
Acute Myeloid Leukemia · Graft Versus Host Disease · Myelodysplastic Syndrome
Recruiting NCT07478848
Radiation, Oral Vancomycin, and CAR-T for B-Cell Lymphomas
Large B Cell Lymphoma · Non Hodgkin Lymphoma (NHL) · Diffuse Large B Cell Lymphoma (DLBCL)
Not yet recruiting NCT06238947
Long-term Outcome Evaluation of Patients Undergoing Autologous Chondrocyte Transplantation Delivered on Biomaterial
Cartilage Injury · Cartilage Disease
Not yet recruiting NCT07679919
BAFF CAR-T Cells (LMY-922) for Treatment of Refractory Hematologic Malignancies
Non-Hodgkin Lymphoma · Chronic Lymphocytic Leukemia · Hairy Cell Leukemia
Not yet recruiting NCT07675291
Rituximab Combining With Low-Dose Mycophenolate Mofetil on Proliferative Lupus Nephritis in Children
Lupus Nephritis
Recruiting NCT07543055
A Phase 1 Study of BPX-601 CAR T-Cell Therapy in Adult Participants With Prostate Cancer That Has Returned, is Resistant to Treatment and Has Spread
Prostate Cancer
Recruiting NCT07234110
CD5 CART for the Treatment of Relapsed and Refractory CD5 Hematological Tumors
Relapsed and Refractory CD5 Hematological Tumors
Recruiting NCT06946485
Universal Anti-CD70 CAR-T (CHT101) Cell Therapy for Relapsed Refractory Systemic Lupus Erythematosus
Systemic Lupus Erythematosus (SLE)
Recruiting NCT07400029
A Study of Obecabtagene Autoleucel in People With B-cell Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia
Enrolling by invitation NCT06027879
Anti-viral T-cell Therapy by Gamma Capture
Adenovirus · Cytomegalovirus Infections · Epstein-Barr Virus Infections
Recruiting NCT05952804
IVIG for Infection Prevention After CAR-T-Cell Therapy
Hematologic Malignancies
Recruiting NCT06815029
Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma
Recurrent Astrocytoma, IDH-Mutant, Grade 3 · Recurrent Astrocytoma, IDH-Mutant, Grade 4 · Recurrent Glioblastoma
Recruiting NCT07347418
CD64 CAR T Cell Therapy in Adults With Relapsed and/or Refractory AML
Refractory Acute Myeloid Leukemia (AML) · Relapsed Acute Myeloid Leukemia (AML) · Myelodysplastic Syndrome
Not yet recruiting NCT07646210
HiCM-188 Cell Therapy in Adults With Advanced Heart Failure Undergoing Heart Bypass Surgery
Advanced Heart Failure · Ischemic Heart Failure
Not yet recruiting NCT07674147
RD06-05 Universal CD19/BCMA CAR-T for Refractory Pediatric Autoimmune Diseases
Autoimmune Diseases · SLE - Systemic Lupus Erythematosus · SSc-Systemic Sclerosis
Recruiting NCT06236139
Cell Therapy (STEAP1 CART) With Enzalutamide for the Treatment of Patients With Metastatic Castration-Resistant Prostate Cancer
Metastatic Castration-Resistant Prostate Carcinoma · Metastatic Prostate Adenocarcinoma · Stage IVB Prostate Cancer AJCC v8
Recruiting NCT06961357
Clinical Trial of CD40L-augmented TIL for Patients With Advanced Melanoma
Melanoma
Not yet recruiting NCT07670260
GoFast CAR T-Cell Therapy for Recurrent Refractory B-Cell Lymphoma
Relapsed or Refractory Large B-cell Lymphoma
Recruiting NCT06895473
Intrathecal Cytarabine, Methotrexate, and Hydrocortisone for the Prevention of High-Grade Chimeric Antigen Receptor T-Cell-Associated Neurotoxicity Syndrome
Hematopoietic and Lymphatic System Neoplasm
Recruiting NCT06469190
An Exploratory Clinical Study of Anti-CD19 CAR NK Cell (KN5501) in the Treatment of Relapsed/Refractory Immune Nephropathy
Nephropathy
Recruiting NCT07668557
Anti-CD33-CLL1 CAR-T Cells (ICG415) for the Treatment of Relapsed/Refractory Acute Myeloid Leukemia
Acute Myeloid Leukemia (AML)
Recruiting NCT07575971
Exploratory Study of CD22/CD19 Dual-Target CAR-T Cell Therapy as Consolidation Treatment After First Remission in High-Risk B-Cell Acute Lymphoblastic Leukemia
B-cell Acute Lymphoblastic Leukemia
Recruiting NCT07424157
Long-Term Follow-Up of Subjects Treated With Seattle Children's Therapeutics Gene Therapy Products
CAR T Cell · CAR T Cell Therapy
Recruiting NCT05848622
Gait Rehabilitation to Treat FastOA
Anterior Cruciate Ligament Injuries · Post-traumatic Osteoarthritis · Knee Osteoarthritis
Enrolling by invitation NCT07499128
Continuous Temperature Monitoring (CTM) for Cytokine Release Syndrome (CRS), an Immune-Related Adverse Event
Cytokine Release Syndrome · Neoplasms · Lymphoma
Recruiting NCT07453095
Study With Glofitamab in Patients With MCL and Inadequate Response or Relapse Following CAR T-cell Therapy
Mantle Cell Lymphoma
Not yet recruiting NCT07488923
A First-in-human (FIH), Phase 1 Study of ML261, an Autologous Potency Enhanced Anti-DLL3 CAR T Cell Therapy, in Participants With R/R SCLC or Select NECs (SPECTRAL-1)
Small Cell Lung Cancer (SCLC ) · Extrapulmonary Neuroendocrine Carcinoma (EP-NEC) · Gastroenteropancreatic NEC (GEP NEC)
Recruiting NCT03588975
A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee
Chondral Defect · Osteochondritis Dissecans (OCD) · Articular Cartilage Defect
Recruiting NCT06197672
Chimeric Antigen Receptor T Cell Redirected to Target CD4 Positive Relapsed Refractory Acute Myeloid Leukemia (AML ) as a Bridge to Allogeneic Stem Cell Transplant
Acute Myeloid Leukemia
Recruiting NCT07665021
Gene-Modified Stem Cell Therapy for Children With Autosomal Recessive Osteopetrosis (ARO)
Osteopetrosis
Not yet recruiting NCT07665307
Delayed Toxicities Post-CAR-T
Multiple Myeloma
Recruiting NCT06071624
Chimeric Antigen Receptor T Cell Therapy Redirected to CD4 (CD4CAR)as a Second Line Treatment for Chronic Myelomonocytic Leukemia, CMML.
Chronic Myelomonocytic Leukemia
Recruiting NCT04016129
CAR-T Immunotherapy Targeting CD19- ALL
B-cell Leukemia
Recruiting NCT05437328
GD2/CD56 Bi-specific CAR-T Cell Therapy
Malignant Disease
Recruiting NCT04033302
Multi-CAR T Cell Therapy Targeting CD7-positive Malignancies
T-cell Acute Lymphoblastic Leukemia · T-cell Acute Lymphoblastic Lymphoma · Acute Myeloid Leukemia
Recruiting NCT03356782
Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas
Sarcoma · Osteoid Sarcoma · Ewing Sarcoma
Recruiting NCT04430530
4SCAR-T Therapy Post CD19-targeted Immunotherapy
CD19 Negative B-cell Malignancies
Recruiting NCT03356795
Intervention of CAR-T Against Cervical Cancer
Cervical Cancer
Recruiting NCT04430595
Multi-4SCAR-T Therapy Targeting Breast Cancer
Breast Cancer
Recruiting NCT06435897
Autoimmune Disease Treatment With Mesenchymal Stem Cells (MSCs) and CAR-T Cells
Autoimmune Diseases
Recruiting NCT05438368
GD2/CD70 Bi-specific CAR-T Cell Therapy
Cancer Disease
Recruiting NCT03222674
Multi-CAR T Cell Therapy for Acute Myeloid Leukemia
Acute Myeloid Leukemia
Recruiting NCT05437341
PSMA/CD70 Bi-specific CAR-T Cell Therapy
Cancer Disease
Recruiting NCT04429438
Multi-CAR-T Cells Targeting B Cell Lymphomas
B Cell Lymphoma (BCL)
Recruiting NCT05436509
CD19/79b Bi-specific CAR-T Cell Therapy
B Cell Malignancies
Recruiting NCT06429150
Frontline Combination CAR-T Cell Therapy for Multiple Myeloma or Plasmacytoma
Multiple Myeloma · Plasmacytoma
Recruiting NCT03185468
Intervention of Bladder Cancer by CAR-T
Bladder Cancer · Urothelial Carcinoma Bladder