/* Lechu Group — Clinical Trials in China
   Palette and type follow cart.hospital: mint #41DAA4, cyan #41C3DA, navy #1f2937,
   Nunito (body) + Unbounded (headings). Design tokens up top (onco.hospital pattern). */

:root {
  --mint: #41daa4;
  --cyan: #41c3da;
  --navy: #1f2937;
  --ink: #24303f;
  --muted: #64748b;
  --green-text: #0e7f66;
  --cyan-text: #18768a;
  --bg: #f8faf9;
  --card: #ffffff;
  --line: #e2e8f0;
  --radius: 14px;
  --maxw: 1080px;
}

* { box-sizing: border-box; }
html { scroll-behavior: smooth; scroll-padding-top: 1rem; }
body {
  margin: 0;
  font-family: 'Nunito', system-ui, sans-serif;
  color: var(--ink);
  background: var(--bg);
  line-height: 1.55;
}
h1, h2, h3 { font-family: 'Unbounded', sans-serif; color: var(--navy); line-height: 1.2; overflow-wrap: anywhere; }
a { color: var(--green-text); text-decoration: none; }
a:hover { text-decoration: underline; }
a:focus-visible, button:focus-visible, input:focus-visible, select:focus-visible, textarea:focus-visible, summary:focus-visible {
  outline: 3px solid var(--cyan); outline-offset: 3px;
}
.skip-link {
  position: fixed; left: 1rem; top: 1rem; z-index: 100; transform: translateY(-160%);
  background: var(--navy); color: #fff; border-radius: 8px; padding: .7rem 1rem; font-weight: 700;
}
.skip-link:focus { transform: translateY(0); }

.site-head {
  display: flex; justify-content: space-between; align-items: center; gap: 1rem;
  max-width: var(--maxw); margin: 0 auto; padding: 1rem 1.25rem;
}
.site-head .logo { font-family: 'Unbounded', sans-serif; font-size: 1.02rem; color: var(--navy); }
.site-head .logo em { color: var(--green-text); font-style: normal; }
.site-head nav { display: flex; gap: 1.1rem; align-items: center; flex-wrap: wrap; }
.site-head nav a { color: var(--ink); font-weight: 600; }
.mobile-menu { display: none; }
.lang-switch {
  border: 1px solid var(--line); border-radius: 999px; padding: .25rem .7rem;
  font-size: .85rem; font-weight: 700; background: var(--card);
}
.lang-switch i { font-style: normal; color: var(--line); margin: 0 .35rem; }
.lang-switch b { color: var(--green-text); }
.lang-switch a { color: var(--muted); }

.crumbs { max-width: var(--maxw); margin: 0 auto; padding: 0 1.25rem; font-size: .85rem; color: var(--muted); }
.crumbs .sep { margin: 0 .3rem; }

main { max-width: var(--maxw); margin: 0 auto; padding: 0 1.25rem 3rem; }
main:focus { outline: none; }
.section { margin: 2.5rem 0; }
.section.highlight { background: var(--card); border: 1px solid var(--line); border-radius: var(--radius); padding: 1.5rem; }

.hero { padding: 3rem 0 1rem; }
.hero .kicker { text-transform: uppercase; letter-spacing: .12em; font-size: .78rem; color: var(--cyan-text); font-weight: 700; }
.hero h1 { font-size: clamp(1.7rem, 4.5vw, 2.8rem); margin: .4rem 0 1rem; }
.hero h1 em { font-style: normal; color: var(--green-text); }
.hero .lead { max-width: 46rem; font-size: 1.06rem; }
.hero-cta { display: flex; gap: .8rem; margin: 1.4rem 0; flex-wrap: wrap; }
.hero-stat { color: var(--muted); }
.hero-stat strong { color: var(--navy); font-size: 1.2rem; }
.trust-strip {
  display: flex; flex-wrap: wrap; gap: .55rem 1.2rem; list-style: none; margin: 1.2rem 0; padding: 0;
  color: var(--ink); font-size: .9rem; font-weight: 600;
}
.trust-strip li::before { content: '✓'; color: var(--green-text); font-weight: 700; margin-right: .4rem; }

/* Prominent hero search (Trial Atlas pattern) */
.hero-search {
  display: grid; grid-template-columns: 1fr; gap: .6rem;
  background: var(--card); border: 1px solid var(--line); border-radius: 16px;
  padding: 1rem; margin: 1.6rem 0 .7rem;
  box-shadow: 0 10px 30px rgba(31, 41, 55, .08);
}
@media (min-width: 820px) {
  .hero-search { grid-template-columns: repeat(2, 1fr); }
  .hero-search .search-query { grid-column: 1 / -1; }
  .hero-search-actions { grid-column: 1 / -1; }
}
.hero-search input, .hero-search select {
  width: 100%; font: inherit; font-size: 1rem; padding: .85rem 1rem;
  border: 1px solid var(--line); border-radius: 12px; background: #f6f9f8;
}
.form-field { display: grid; align-content: start; gap: .3rem; min-width: 0; font-size: .86rem; font-weight: 700; color: var(--ink); }
.hero-search-actions { display: flex; align-items: center; flex-wrap: wrap; gap: .7rem 1rem; }
.more-filters { font-weight: 700; }
.hero-search .btn { padding: .85rem 1.6rem; font-size: 1rem; border: none; cursor: pointer; }
.hero-examples { font-size: .85rem; color: var(--muted); }
.chip {
  display: inline-block; border-bottom: 1px dashed var(--cyan);
  color: var(--ink); margin-right: .5rem;
}
.chip:hover { color: var(--navy); text-decoration: none; border-bottom-style: solid; }
.sample-note { background: #fff7e6; border: 1px solid #f5d78e; border-radius: 8px; padding: .7rem 1rem; max-width: 46rem; }

.btn {
  min-height: 44px; display: inline-flex; align-items: center; justify-content: center; background: var(--mint); color: var(--navy);
  font-weight: 700; padding: .7rem 1.4rem; border-radius: 999px; border: 2px solid var(--mint);
  font: inherit; cursor: pointer;
}
.btn:hover { text-decoration: none; filter: brightness(.95); }
.btn-ghost { background: transparent; color: var(--navy); }
.btn-small { padding: .4rem 1rem; font-size: .9rem; }
.btn-block { display: flex; text-align: center; margin-top: 1rem; }

.cat-grid { display: grid; grid-template-columns: repeat(auto-fill, minmax(230px, 1fr)); gap: .9rem; }
.cat-card {
  background: var(--card); border: 1px solid var(--line); border-radius: var(--radius);
  padding: 1rem 1.1rem; display: flex; flex-direction: column; gap: .25rem; color: var(--ink);
}
.cat-card:hover { border-color: var(--mint); text-decoration: none; }
.cat-card span { color: var(--muted); font-size: .88rem; }

.steps { max-width: 46rem; padding-left: 1.2rem; }
.steps li { margin-bottom: .8rem; }

.search-bar { display: grid; grid-template-columns: 1fr; gap: .6rem; margin: 1rem 0; }
@media (min-width: 760px) {
  .search-bar { grid-template-columns: repeat(3, 1fr); }
  .search-bar .search-query, .search-actions { grid-column: 1 / -1; }
}
.search-bar input, .search-bar select {
  width: 100%; font: inherit; padding: .72rem .9rem; border: 1px solid var(--line); border-radius: 10px; background: var(--card);
}
.search-intro { max-width: 48rem; }
.search-note { max-width: 48rem; margin-top: .4rem; }
.search-actions { display: flex; align-items: center; }
.search-actions .btn { padding: .48rem 1rem; }
.result-count { color: var(--ink); font-weight: 700; }
.empty-state { background: var(--card); border: 1px dashed var(--line); border-radius: var(--radius); padding: 1.5rem; color: var(--muted); }

.cards { display: grid; gap: .9rem; }
.card, .trial {
  background: var(--card); border: 1px solid var(--line); border-radius: var(--radius); padding: 1.1rem 1.25rem;
}
.card h3 { margin: .35rem 0; font-family: 'Nunito', system-ui, sans-serif; font-size: 1.08rem; line-height: 1.35; }
.card h3 a { color: var(--navy); }
.card-top { display: flex; gap: .7rem; align-items: center; font-size: .82rem; }
.nct { color: var(--muted); font-weight: 700; letter-spacing: .04em; }
.status { font-weight: 700; padding: .15rem .6rem; border-radius: 999px; font-size: .78rem; }
.st-RECRUITING { background: #e3f9f0; color: #0b7a55; }
.st-NOT_YET_RECRUITING { background: #fff3e0; color: #a05a00; }
.st-ENROLLING_BY_INVITATION { background: #ede9fe; color: #5b21b6; }
.tag {
  display: inline-block; background: #eef4f2; border-radius: 6px; padding: .1rem .55rem;
  font-size: .78rem; color: var(--ink); margin-right: .25rem;
}
.tag-city { background: #e6f6fa; }
.tag-cond { background: #f1eefe; }
.cond { color: var(--muted); font-size: .9rem; margin: .3rem 0 0; }

.trial h1 { font-family: 'Nunito', system-ui, sans-serif; font-size: clamp(1.45rem, 3vw, 2rem); line-height: 1.2; }
.trial-grid { display: grid; gap: 1.5rem; margin-top: 1rem; }
@media (min-width: 860px) { .trial-grid { grid-template-columns: 2fr 1fr; } }
.trial-side { background: #f4f8f7; border-radius: var(--radius); padding: 1rem 1.2rem; height: fit-content; }
.trial-side h2 { margin: 0 0 .6rem; font-family: 'Nunito', system-ui, sans-serif; font-size: 1.18rem; }
.trial-side dt { font-size: .78rem; text-transform: uppercase; letter-spacing: .08em; color: var(--muted); margin-top: .7rem; }
.trial-side dd { margin: 0; font-weight: 600; }
.side-note { font-size: .82rem; color: var(--muted); }
.registry-links li, .sites li { margin-bottom: .35rem; }
.trial-contents {
  display: flex; flex-wrap: wrap; gap: .35rem .9rem; align-items: center;
  margin: 1rem 0; padding: .75rem 1rem; background: #f4f8f7; border-radius: 10px; font-size: .9rem;
}
.trial-contents a { text-decoration: underline; text-underline-offset: 2px; }
.trial-main h2[id] { scroll-margin-top: 1rem; }

.note { font-size: .85rem; color: var(--muted); }

/* Comprehensive trial page */
.official-title { color: var(--muted); font-size: .92rem; }
.detailed { margin: .8rem 0; border: 1px solid var(--line); border-radius: 10px; padding: .6rem .9rem; background: #fbfdfc; }
.detailed summary { cursor: pointer; font-weight: 700; color: var(--navy); }
.location-group { border-top: 1px solid var(--line); padding: .75rem 0; }
.location-group:last-child { border-bottom: 1px solid var(--line); }
.location-group summary { cursor: pointer; color: var(--navy); font-weight: 700; }
.location-group .sites { margin-bottom: .2rem; }
.iv-list, .outcomes, .refs { padding-left: 1.2rem; }
.iv-list li, .outcomes li, .refs li { margin-bottom: .5rem; }
.iv-desc { color: var(--muted); font-size: .88rem; }
.outcomes .tf { color: var(--muted); font-size: .85rem; }
.design-dl { display: grid; grid-template-columns: repeat(auto-fill, minmax(200px, 1fr)); gap: .6rem; margin: .5rem 0; }
.design-dl dt { font-size: .75rem; text-transform: uppercase; letter-spacing: .07em; color: var(--muted); }
.design-dl dd { margin: 0; font-weight: 600; }
.site-contact { color: var(--muted); font-size: .85rem; }
.ids { color: var(--muted); font-size: .88rem; }
.side-sub { font-weight: 400; font-size: .82rem; color: var(--muted); }

/* Eligibility criteria */
.crit-h { font-size: 1rem; margin: 1.1rem 0 .4rem; }
.crit-inc { color: #0b7a55; }
.crit-exc { color: #a04545; }
.crit-list { margin: .3rem 0 .8rem; padding-left: 1.3rem; }
.crit-list li { margin-bottom: .3rem; }

/* Support form */
.sup-form { max-width: 34rem; display: grid; gap: .9rem; margin: 1.2rem 0; }
.sup-form label { display: grid; gap: .3rem; font-weight: 600; font-size: .92rem; }
.sup-form input, .sup-form textarea {
  font: inherit; padding: .65rem .9rem; border: 1px solid var(--line); border-radius: 10px; background: var(--card);
}
.sup-form select { font: inherit; padding: .65rem .9rem; border: 1px solid var(--line); border-radius: 10px; background: var(--card); }
.field-help { max-width: 34rem; margin: 0; color: var(--muted); font-size: .85rem; }
.sup-row { display: grid; gap: .9rem; }
@media (min-width: 640px) { .sup-row { grid-template-columns: 1fr 1fr; } }
.sup-consent { display: flex !important; flex-direction: row; align-items: flex-start; gap: .6rem; font-weight: 400 !important; font-size: .85rem; color: var(--muted); }
.sup-consent input { width: 1.1rem; height: 1.1rem; margin-top: .15rem; }
.sup-form button { justify-self: start; cursor: pointer; }
.support-direct {
  display: grid; gap: 1rem; margin: 1.3rem 0 1.8rem; padding: 1.1rem 1.2rem;
  background: #f4f8f7; border: 1px solid var(--line); border-radius: var(--radius);
}
.support-direct h2 { margin: 0 0 .3rem; font-family: 'Nunito', system-ui, sans-serif; font-size: 1.18rem; }
.support-direct p { margin: 0; }
.support-channels { display: flex; flex-wrap: wrap; gap: .6rem; }
@media (min-width: 760px) {
  .support-direct { grid-template-columns: 1fr auto; align-items: center; }
}

/* Patient-friendly blocks */
.start-card strong { font-size: 1rem; }
.start-card span, .story-card span { line-height: 1.45; }
.story-card { border-left: 4px solid var(--mint); font-style: normal; }
.guide-link { font-size: .9rem; }
.glossary dt { font-weight: 700; color: var(--navy); margin-top: .8rem; }
.glossary dd { margin: .15rem 0 0; }
.guide h2, .about h2 { margin-top: 1.8rem; }

/* Plain-language summaries and saved trials */
.sr-only {
  position: absolute !important; width: 1px; height: 1px; padding: 0; margin: -1px;
  overflow: hidden; clip: rect(0, 0, 0, 0); white-space: nowrap; border: 0;
}
.card-top-split { justify-content: space-between; align-items: flex-start; }
.save-trial {
  min-height: 36px; border: 1px solid var(--green-text); border-radius: 999px; background: #fff;
  color: var(--green-text); padding: .38rem .72rem; font: inherit; font-weight: 700; cursor: pointer;
}
.save-trial:hover, .save-trial[aria-pressed="true"] { background: #e5f6f0; }
.shortlist-count {
  display: inline-grid; place-items: center; min-width: 1.35rem; height: 1.35rem; margin-left: .22rem;
  border-radius: 999px; background: var(--mint); color: var(--navy); font-size: .75rem; font-weight: 800;
}
.patient-summary {
  margin: 1.2rem 0 1.5rem; padding: 1.15rem; border: 2px solid #b9ddd2;
  border-radius: var(--radius); background: #f5fbf9;
}
.patient-summary h2 { margin: 0 0 .35rem; font-size: 1.35rem; }
.patient-summary-head { display: flex; align-items: flex-start; justify-content: space-between; gap: 1rem; }
.patient-summary-head .kicker { margin-top: 0; }
.save-trial-prominent { flex: 0 0 auto; }
.patient-summary-intro { margin: 0 0 1rem; color: var(--muted); }
.patient-summary-grid { display: grid; gap: .8rem; margin: 0; }
.patient-summary-grid > div { padding: .8rem; border-radius: 10px; background: #fff; border: 1px solid var(--line); }
.patient-summary-grid dt { color: var(--navy); font-weight: 800; }
.patient-summary-grid dd { margin: .25rem 0 0; }
.patient-summary .save-trial { margin-top: 1rem; }
.patient-summary-note { margin: .85rem 0 0; font-size: .86rem; color: var(--muted); }
@media (min-width: 720px) { .patient-summary-grid { grid-template-columns: repeat(2, minmax(0, 1fr)); } .patient-summary-grid > :last-child { grid-column: 1 / -1; } }
@media (max-width: 560px) { .patient-summary-head { display: grid; } .save-trial-prominent { justify-self: start; } }

.freshness-note, .freshness-warning { margin: .7rem 0; padding: .65rem .8rem; border-radius: 9px; font-size: .86rem; }
.freshness-note { color: var(--muted); background: #f4f8f7; }
.freshness-warning { color: #6e3f0c; background: #fff4df; border: 1px solid #e7c681; }

.shortlist-toolbar { display: flex; flex-wrap: wrap; align-items: center; gap: .65rem; margin: 1.1rem 0; }
.text-button, .shortlist-remove {
  border: 0; background: transparent; color: #9a3434; padding: .45rem; font: inherit; text-decoration: underline; cursor: pointer;
}
.share-field { display: grid; gap: .3rem; max-width: 48rem; margin-bottom: .5rem; }
.share-field label { font-size: .85rem; font-weight: 700; }
.share-field input { width: 100%; font: inherit; padding: .65rem .8rem; border: 1px solid var(--line); border-radius: 9px; background: #f8faf9; }
.empty-state { padding: 1.1rem; border: 1px dashed #9db6ad; border-radius: var(--radius); background: #f8fbfa; }
.loading-state, .missing-state { padding: .85rem 1rem; border-radius: 10px; background: #f4f8f7; color: var(--muted); }
.loading-error, .missing-state { color: #6e3f0c; background: #fff4df; border: 1px solid #e7c681; }
.missing-state { margin: .8rem 0; }
.compare-wrap { max-width: 100%; overflow-x: auto; margin: 1rem 0; border: 1px solid var(--line); border-radius: var(--radius); }
.compare-table, .info-table { width: 100%; min-width: 720px; border-collapse: collapse; background: #fff; }
.compare-table th, .compare-table td, .info-table th, .info-table td { padding: .75rem; border-right: 1px solid var(--line); border-bottom: 1px solid var(--line); text-align: left; vertical-align: top; }
.compare-table thead th { min-width: 210px; background: #f4f8f7; }
.compare-table thead th:first-child { min-width: 130px; }
.compare-table tbody th, .info-table th { color: var(--navy); background: #f8faf9; }
.compare-nct { display: block; margin: .35rem 0; color: var(--muted); font-size: .78rem; font-weight: 500; }
.shortlist-remove { padding-left: 0; font-size: .82rem; }

/* Trust, logistics, and legal content */
.trust-grid { display: grid; gap: .8rem; margin: 1.25rem 0; }
.trust-grid article { display: grid; gap: .25rem; padding: 1rem; border: 1px solid var(--line); border-radius: var(--radius); background: #f8fbfa; }
.trust-grid strong { color: var(--navy); font-size: 1.05rem; }
.trust-grid span, .source-note { color: var(--muted); font-size: .88rem; }
@media (min-width: 720px) { .trust-grid { grid-template-columns: repeat(2, minmax(0, 1fr)); } }
.contact-steps { list-style: none; counter-reset: step; padding: 0; display: grid; gap: .7rem; }
.contact-steps li { counter-increment: step; display: grid; grid-template-columns: 2.1rem 1fr; column-gap: .7rem; padding: .85rem; border-left: 3px solid var(--mint); background: #f8fbfa; }
.contact-steps li::before { content: counter(step); grid-row: 1 / 3; display: grid; place-items: center; width: 2rem; height: 2rem; border-radius: 50%; background: var(--navy); color: #fff; font-weight: 800; }
.contact-steps span { color: var(--muted); }
.legal-page { max-width: 52rem; }
.legal-page h2 { margin-top: 1.8rem; }
.cost-callout, .registry-note { margin: 1.2rem 0; padding: 1rem; border-radius: var(--radius); background: #f0f8f5; border-left: 4px solid var(--green-text); }
.cost-callout p { margin: .35rem 0 0; }
.check-list { padding-left: 1.25rem; }
.check-list li { margin-bottom: .55rem; }

@media print {
  .site-head, .crumbs, .site-foot, .shortlist-toolbar, .share-field, #share-status, .shortlist-remove { display: none !important; }
  main { max-width: none; padding: 0; }
  .compare-wrap { overflow: visible; border: 0; }
  .compare-table { min-width: 0; font-size: 9pt; }
  .compare-table th, .compare-table td { padding: 5pt; }
  a { color: inherit; text-decoration: none; }
}

/* Category pager */
.pager { display: flex; justify-content: space-between; align-items: center; margin: 1rem 0; color: var(--muted); }
.pager a { font-weight: 700; }

.site-foot { background: var(--navy); color: #cbd5e1; margin-top: 3rem; }
.site-foot a { color: var(--mint); }
.site-foot h3 { color: #fff; font-size: 1rem; }
.foot-grid { max-width: var(--maxw); margin: 0 auto; padding: 2rem 1.25rem; display: grid; gap: 1.5rem; }
@media (min-width: 760px) { .foot-grid { grid-template-columns: 1fr 2fr; } }
.disclaimer { font-size: .8rem; color: #94a3b8; }
.foot-links { display: flex; flex-wrap: wrap; gap: .45rem 1rem; margin-top: .8rem; font-size: .86rem; }

@media (max-width: 759px) {
  html { scroll-behavior: auto; }
  .site-head { align-items: center; padding: .8rem 1rem; }
  .site-head .logo { max-width: 235px; font-size: .86rem; line-height: 1.35; }
  .desktop-nav { display: none !important; }
  .mobile-menu { display: block; position: relative; margin-left: auto; }
  .mobile-menu > summary {
    min-height: 44px; display: flex; align-items: center; list-style: none; cursor: pointer;
    border: 1px solid var(--line); border-radius: 999px; background: var(--card); padding: .55rem .9rem; font-weight: 700;
  }
  .mobile-menu > summary::-webkit-details-marker { display: none; }
  .mobile-menu > summary::after { content: '☰'; margin-left: .45rem; color: var(--green-text); }
  .mobile-menu[open] > summary::after { content: '×'; }
  .mobile-menu nav {
    position: absolute; right: 0; top: calc(100% + .5rem); z-index: 20; width: min(300px, calc(100vw - 2rem));
    display: grid; align-items: stretch; gap: .25rem; padding: .75rem; background: var(--card);
    border: 1px solid var(--line); border-radius: var(--radius); box-shadow: 0 14px 35px rgba(31, 41, 55, .16);
  }
  .mobile-menu nav > a:not(.btn) { min-height: 44px; display: flex; align-items: center; padding: .45rem .55rem; }
  .mobile-menu .lang-switch { justify-self: start; margin: .35rem .45rem; }
  .crumbs { padding: .45rem 1rem 0; overflow-x: auto; white-space: nowrap; }
  main { padding: 0 1rem 2.5rem; }
  .hero { padding: 1.6rem 0 .5rem; }
  .hero h1 { font-size: clamp(1.72rem, 9vw, 2.2rem); }
  .hero .lead { font-size: 1rem; }
  .trust-strip { display: grid; gap: .45rem; }
  .hero-search { padding: .8rem; margin-top: 1.2rem; }
  .hero-search-actions { align-items: stretch; }
  .hero-search-actions .btn { width: 100%; }
  .section { margin: 2rem 0; }
  .card, .trial { padding: 1rem; }
  .card-top { flex-wrap: wrap; }
  .trial { margin-top: 1.2rem; }
  .trial-grid { gap: 1rem; }
  .trial-side { order: -1; }
  .trial-contents { align-items: flex-start; }
  .trial-contents strong { flex-basis: 100%; }
  .official-title { overflow-wrap: anywhere; }
  .sup-form input, .sup-form textarea, .sup-form select, .search-bar input, .search-bar select, .hero-search input, .hero-search select { font-size: 16px; }
  .support-channels { display: grid; grid-template-columns: 1fr; }
  .support-channels .btn { width: 100%; }
}

@media (prefers-reduced-motion: reduce) {
  html { scroll-behavior: auto; }
}